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Pregled bibliografske jedinice broj: 965822

Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery


Škalamera, Đani; Matković, Marija; Uzelac, Lidija; Kralj, Marijeta; Mlinarić-Majerski, Kata; Bohne, Cornelia; Basarić, Nikola
Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery // Organic & biomolecular chemistry, 16 (2018), 46; 8908-8912 doi:10.1039/C8OB02605J (međunarodna recenzija, članak, znanstveni)


Naslov
Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery

Autori
Škalamera, Đani ; Matković, Marija ; Uzelac, Lidija ; Kralj, Marijeta ; Mlinarić-Majerski, Kata ; Bohne, Cornelia ; Basarić, Nikola

Izvornik
Organic & biomolecular chemistry (1477-0520) 16 (2018), 46; 8908-8912

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Drug delivery ; Cucurbit[n]uril ; Host-guest complexes ; Photochemistry ; Quinone methide ; Supramolecular chemistry ; Time-resolved spectroscopy

Sažetak
We demonstrate a proof of principle for a new approach in the development of a drug delivery system. Positively charged prodrug (phenol) can form stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is neutral molecule and forms less stable complex with CB[7].

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (Marijeta Kralj, )
HRZZ-IP-2014-09-6312 - Supramolekulska kontrola fotokemijskih reakcija eliminacije (Nikola Basarić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Arts & Humanities Citation Index (A&HCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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