Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery (CROSBI ID 256152)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Škalamera, Đani ; Matković, Marija ; Uzelac, Lidija ; Kralj, Marijeta ; Mlinarić-Majerski, Kata ; Bohne, Cornelia ; Basarić, Nikola
engleski
Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery
We demonstrate a proof of principle for a new approach in the development of a drug delivery system. Positively charged prodrug (phenol) can form stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is neutral molecule and forms less stable complex with CB[7].
Drug delivery ; Cucurbit[n]uril ; Host-guest complexes ; Photochemistry ; Quinone methide ; Supramolecular chemistry ; Time-resolved spectroscopy
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Podaci o izdanju
16 (46)
2018.
8908-8912
objavljeno
1477-0520
1477-0539
10.1039/C8OB02605J
Povezanost rada
Kemija, Temeljne medicinske znanosti