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Pregled bibliografske jedinice broj: 965677

Chromatin remodeling in Drosophila preblastodermic embryo extract


Šatović, Eva; Font-Mateu, Jofre; Carbonell, Albert; Beato, Miguel; Azorín, Fernando
Chromatin remodeling in Drosophila preblastodermic embryo extract // Scientific Reports, 8 (2018), 10927; 10927, 8 doi:10.1038/s41598-018-29129-8 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 965677 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Chromatin remodeling in Drosophila preblastodermic embryo extract

Autori
Šatović, Eva ; Font-Mateu, Jofre ; Carbonell, Albert ; Beato, Miguel ; Azorín, Fernando

Izvornik
Scientific Reports (2045-2322) 8 (2018), 10927; 10927, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chromatin ; remodeling ; Drosophila melanogaster ; histone

Sažetak
Chromatin is known to undergo extensive remodeling during nuclear reprogramming. However, the factors and mechanisms involved in this remodeling are still poorly understood and current experimental approaches to study it are not best suited for molecular and genetic analyses. Here we report on the use of Drosophila preblastodermic embryo extracts (DREX) in chromatin remodeling experiments. Our results show that incubation of somatic nuclei in DREX induces changes in chromatin organization similar to those associated with nuclear reprogramming, such as rapid binding of the germline specific linker histone dBigH1 variant to somatic chromatin, heterochromatin reorganization, changes in the epigenetic state of chromatin, and nuclear lamin disassembly. These results raise the possibility of using the powerful tools of Drosophila genetics for the analysis of chromatin changes associated with this essential process.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Eva Šatović (autor)

Citiraj ovu publikaciju

Šatović, Eva; Font-Mateu, Jofre; Carbonell, Albert; Beato, Miguel; Azorín, Fernando
Chromatin remodeling in Drosophila preblastodermic embryo extract // Scientific Reports, 8 (2018), 10927; 10927, 8 doi:10.1038/s41598-018-29129-8 (međunarodna recenzija, članak, znanstveni)
Šatović, E., Font-Mateu, J., Carbonell, A., Beato, M. & Azorín, F. (2018) Chromatin remodeling in Drosophila preblastodermic embryo extract. Scientific Reports, 8 (10927), 10927, 8 doi:10.1038/s41598-018-29129-8.
@article{article, year = {2018}, pages = {8}, DOI = {10.1038/s41598-018-29129-8}, chapter = {10927}, keywords = {chromatin, remodeling, Drosophila melanogaster, histone}, journal = {Scientific Reports}, doi = {10.1038/s41598-018-29129-8}, volume = {8}, number = {10927}, issn = {2045-2322}, title = {Chromatin remodeling in Drosophila preblastodermic embryo extract}, keyword = {chromatin, remodeling, Drosophila melanogaster, histone}, chapternumber = {10927} }
@article{article, year = {2018}, pages = {8}, DOI = {10.1038/s41598-018-29129-8}, chapter = {10927}, keywords = {chromatin, remodeling, Drosophila melanogaster, histone}, journal = {Scientific Reports}, doi = {10.1038/s41598-018-29129-8}, volume = {8}, number = {10927}, issn = {2045-2322}, title = {Chromatin remodeling in Drosophila preblastodermic embryo extract}, keyword = {chromatin, remodeling, Drosophila melanogaster, histone}, chapternumber = {10927} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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