engleski

Platelet count, mean platelet volume and plasma fibrinogen level in the acute phase of different types of stroke

Introduction: Increased plasma fibrinogen is known risk factor related to atherosclerosis. Large platelets are more reactive and aggregate more easily. Aim of our study was to compare plasma fibrinogen, platelet count and mean platelet volume (MPV) in different types of stroke. Methods: We analysed laboratory and anamnestic data from 100 patients admitted to the ICU for acute stroke. Their average age was 70±15 years and 56% were female. They were divided into three groups depending on the type of stroke. Group I with ischemic stroke (57%), group II with intracerebral haemorrhage (ICH, 26%) and group III with subarachnoidal haemorrhage (SAH, 17%). Results: We found that pts. with ischemic stroke had significantly higher fibrinogen levels than in other two groups (4.9±1.5 ; 4.1±1.1 ; 4.0±1.3 g/L, p I vs. II = 0.02, p I vs. III = 0.03, P II vs. III NS). Although pts. from group III had slightly greater platelet count (243±96 vs. 217±65 and 211±61x10/9/L) and greater MPV (8.3±0.9 vs. 8.1±0.9 and 8.2±1.0 fL) that difference was not statistically significant. We also found that pts. from group I taking acetylsalicylic acid (ASA) prior to the event had better NIHSS (National Institute of Health Stroke Scale) at admission and mRS (modified Rankin Scale) at the end of acute phase than those not taking ASA (10 vs. 13 and 3.9 vs. 4.4). On the contrary, pts. from group II taking ASA had significantly worse NIHSS and mRS than those not taking ASA (16 vs. 12 and 5.6 vs. 4.2).Conclusion: Plasma fibrinogen is significantly higher in acute ischemic stroke than in ICH or SAH while there was no significant difference in platelet count and MPV in acute phase. Taking ASA before stroke has slight positive impact on outcome in ischemic stroke but great negative in haemorrhagic stroke.

stroke, platelet count, mean platelet volume, plasma fibrinogen level

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