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Pregled bibliografske jedinice broj: 964926

PON1 gene polymorphisms in patients with chronic obstructive pulmonary disease


Grdić Rajković, Marija; Popović-Grle, Sanja; Vukić Dugac, Andrea; Rogić, Dunja; Rako, Ivana; Radić Antolic, Margareta; Beriša, Mirela; Rumora, Lada
PON1 gene polymorphisms in patients with chronic obstructive pulmonary disease // Journal of clinical pathology, 71 (2018), 11; 963-970 doi:10.1136/jclinpath-2018-205194 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 964926 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
PON1 gene polymorphisms in patients with chronic obstructive pulmonary disease

Autori
Grdić Rajković, Marija ; Popović-Grle, Sanja ; Vukić Dugac, Andrea ; Rogić, Dunja ; Rako, Ivana ; Radić Antolic, Margareta ; Beriša, Mirela ; Rumora, Lada

Izvornik
Journal of clinical pathology (0021-9746) 71 (2018), 11; 963-970

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic obstructive pulmonary disease, paraoxonase 1, polymorphisms, Q192R, L55M, -108C>T

Sažetak
Chronic obstructive pulmonary disease (COPD) is characterized with oxidative stress. Paraoxonase 1 (PON1) is an enzyme, coded by pon1 gene, with distinctive antiatherogenic and antioxidative roles. We aimed to investigate the frequencies of Q192R, L55M and -108C>T polymorphisms and association of those polymorphisms with paraoxonase and arylesterase activities in COPD patients. PON1 genotype was determined by PCR-RFLP method. PON1 activity was measured by paraoxon and phenylacetate. Only -108C>T polymorphism resulted in significantly different distribution of genotypes and alleles, with higher frequency of TT genotype and T allele in patients compared to control subjects. Moreover, T allele [OR 2.29 (95% CI 1.54 – 3.41) ; P< 0.001] as well as TT genotype [OR 5.00 (95% CI 2.19 – 11.43) ; P< 0.001] showed an association with the disease. -108C>T polymorphism was suggested as a significant diagnostic predictor for the disease [OR (95%CI) 2.65 (1.53 – 4.59), P=0.001], with an AUC of 0.90 (0.84 - 0.93), and with 83.90% of correctly classified cases. Higher frequency of TT genotype and T allele, could contribute to the observed reduction of PON1 activity in COPD patients. T allele as well as TT genotype are associated with COPD, and the pon1 -108C>T polymorphism could be a potential predictor of the disease.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-1247 - Uloga stresnog proteina Hsp70 u imunosno-upalnom odgovoru kod kronične opstrukcijske plućne bolesti (HRZZ)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Grdić Rajković, Marija; Popović-Grle, Sanja; Vukić Dugac, Andrea; Rogić, Dunja; Rako, Ivana; Radić Antolic, Margareta; Beriša, Mirela; Rumora, Lada
PON1 gene polymorphisms in patients with chronic obstructive pulmonary disease // Journal of clinical pathology, 71 (2018), 11; 963-970 doi:10.1136/jclinpath-2018-205194 (međunarodna recenzija, članak, znanstveni)
Grdić Rajković, M., Popović-Grle, S., Vukić Dugac, A., Rogić, D., Rako, I., Radić Antolic, M., Beriša, M. & Rumora, L. (2018) PON1 gene polymorphisms in patients with chronic obstructive pulmonary disease. Journal of clinical pathology, 71 (11), 963-970 doi:10.1136/jclinpath-2018-205194.
@article{article, year = {2018}, pages = {963-970}, DOI = {10.1136/jclinpath-2018-205194}, keywords = {chronic obstructive pulmonary disease, paraoxonase 1, polymorphisms, Q192R, L55M, -108C>T}, journal = {Journal of clinical pathology}, doi = {10.1136/jclinpath-2018-205194}, volume = {71}, number = {11}, issn = {0021-9746}, title = {PON1 gene polymorphisms in patients with chronic obstructive pulmonary disease}, keyword = {chronic obstructive pulmonary disease, paraoxonase 1, polymorphisms, Q192R, L55M, -108C>T} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • EMBASE (Excerpta Medica)
  • CentralCINAHL
  • Google Scholar
  • PubMed


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