engleski

The effects of n-3 polyunsaturated free fatty acids dietary intake on hemorheology and endothelium-dependent microvascular function

Potential beneficiary effects of dietary or supplementary daily intake of n-3 polyunsaturated fatty acids (n-3 PUFAs), such as α‐linolenic fatty acid, eicosapentaenoic acid, and docosahexaenoic acid on hemorheology and vascular function are currently intensively investigated. Depending on the source of n-3 PUFAs and the study subjects (i.e. healthy individuals or cardiovascular patients) n-3 PUFA supplementation have been shown to have the antitrombotic effects (by decreasing blood viscosity, decreasing FIIc, FIXc, FXc, FVIIc, FVIIa, FXIIa, PAI-1 levels and platelet aggregation/reactivity, enhancing fibrinolysis, but without effects on erythrocyte deformability). They decrease inflammation by decreasing IL-6, MCP-1, TNF-alpha and hsCRP levels, expression of endothelial cell adhesion molecules and significantly affect blood composition of fatty acids. It is well accepted that the metabolites of n-6 PUFA, such as the metabolites of arachidonic acid have very important role in many physiological processes in cardiovascular system.On the other hand, there are controversies in the beneficial effects of n-3 PUFAs consumption on macrovascular function, and studies on microvascular function are rare. Recently we have showed significantly enhanced endothelium-dependent microvascular reactivity to reactive hyperemia in young healthy population. Plasma hsCRP and lipid peroxidation products were decreased and antioxidative enzymes function was enhanced (i.e. increased glutathione peroxidase activity). The possible underlying protective mechanisms of n-3 PUFA intake may be a change in balance of n-6 PUFA metabolites (e.g. prostaglandins and leukotrienes) and n-6 PUFA metabolites (such as resolvins, maresins and protectins), reduced inflammation and decreased vascular oxidative stress

omega-3 fatty acids, hemorrheology, endothelial function, microcirculation

predavanje, međunarodna konferencija, potpora: Croatian National Scientific Center of Excellence for Personalized Health Care Josip Juraj Strosssmayer University of Osijek EU Structural and investment funds grant #KK.01.1.1.01.0010