engleski

Uric acid/creatinine ratio as a biomarker of severity of chronic obstructive pulmonary disease

Background: Oxidative stress plays an important role in chronic obstructive pulmonary disease (COPD). Uric acid is a well-known marker of oxidative stress. Recently, elevated serum uric acid was associated with the risk of airflow limitation. Furthermore, uric acid/creatinine ratio was suggested to be a promising factor in predicting exacerbation risk and disease severity. The aim of this study was to assess uric acid concentration and uric acid/creatinine ratio in stable COPD patients in relation to the severity of the disease. Materials and Methods: We obtained blood samples from stable COPD patients (N=137 ; 86 male and 51 female ; median age 65, range 44-86 years) and matched healthy volunteers (N=95 ; 49 male and 46 female ; median age 64, range 46-83 years). COPD patients were divided into subgroups according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) or new "ABCD" classifications (from 2017), by both mMRC (modified Medical Research Council) and CAT (COPD assessment test) questionaries. Serum uric acid and creatinine concentrations were determined using the Cobas 6000 (Roche Diagnostics) automated biochemical analyzer, and uric acid/creatinine ratio was calculated. Nonparametric statistics using the MedCalc program was used for data analysis. Results: Both uric acid concentration and uric acid/creatinine ratio were significantly increased in COPD patients compared to healthy controls [320 (269-399) µmol/L vs. 292 (249-348) µmol/L, P=0.028 ; and 4.37 (3.78-5.15) vs. 3.88 (3.34-4.43), P<0.001 ; respectively], while creatinine concentration showed no statistical differences [72 (60-84) µmol/L vs. 79 (67-88) µmol/L, P=0.062]. Moreover, uric acid/creatinine ratio was increased in all COPD patients compared to healthy controls regardless of sex (P<0.001). Finally, uric acid/creatinine ratio showed an increase with the severity of the disease according to both GOLD and new "ABCD" classifications (by mMRC and CAT questionaries). Conclusion: Uric acid/creatinine ratio might be a simple, cost-effective biomarker of severity in newly diagnosed COPD patients.

chronic obstructive pulmonary disease ; uric acid ; uric acid/creatinine ratio

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