engleski

Association of lipid profile with the severity of the disease in chronic obstructive pulmonary disease

Background: Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease associated with comorbidities, such as cardiovascular diseases (CVD). Our aim was to assess the relationship between lipid profile and the severity of the disease in COPD patients. Materials and Methods: The study included 95 healthy subjects (49 male and 46 female ; median age 64, range 46-83 years) and 137 COPD patients (86 male and 51 female ; median age 65, range 44- 86 years). COPD patients were subdivided according to new classifications by disease severity (stages A-D), using the mMRC (modified Medical Research Council) and CAT (COPD assessment test) questionnaires. FEV1 and FEV1/FVC were determined by spirometry. Total cholesterol, triglycerides and HDL cholesterol were measured by Cobas c501 (Roche Diagnostics, Switzerland) automated biochemical analyser, while LDL cholesterol was calculated. Data were analysed by MedCalc statistical analysis software. Results: Total cholesterol (P<0.0001), triglycerides (P<0.001) and LDL cholesterol (P<0.001) were lower, while HDL cholesterol was higher in patients with COPD (P=0.038). According to mMRC classification, total (P<0.001) and LDL (P<0.001) cholesterol were lower for all 4 stages compared to healthy controls, and in stage B compared to A, while triglycerides were lower in stages B, C and D compared to healthy controls, and in stages B and C compared to stage A. According to CAT classification, total (P<0.001) and LDL (P<0.001) cholesterol, and triglycerides (P=0.003) were lower for stages B and D compared to healthy controls, and also in stages B and D vs. A for LDL cholesterol. No differences were found in HDL cholesterol levels according to mMRC or CAT classifications. Neither FEV1 or FEV1/FVC were correlated with lipid parameters. Conclusion: Lipid profile measurements could be associated with severity of COPD, but they are lower in COPD patients and are not associated with increased CVD risk in this group of patients.

chronic obstructive pulmonary disease ; cholesterol ; triglycerides

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