engleski

Muscle: An endocrine organ linking physical activity and development of chronic non- communicable diseases/diabetes mellitus.

Sedentary lifestyle is one of the principal causes of non-communicable diseases worldwide. Recently, muscles have been recognized as an important source of cytokines and myokines, molecules with autocrine, paracrine, and endocrine function, and far-reaching effects. It has been postulated that muscles through cytokines can modulate low-grade chronic inflammation, a feature of non- communicable diseases, such as type 2 diabetes, and therefore play an important role in disease postponement and successful treatment. Therefore, physical activity is an integral part of treatment guidelines for type 2 diabetes. Despite increasing evidence of anti- inflammatory effect of PA, much more research is needed to pinpoint the type and intensity of activity with the largest anti- inflammatory effect, as well as the type of patients which would benefit most from this approach, especially in terms of improvement of cardiovascular outcomes.

cardiovascular outcome ; chronic inflammation ; diabetes type 2 ; muscles ; myokines

nije evidentirano