engleski

Selected examples of spontaneous pathology and pathology of aging in GEMs, NSG and NOD mice

Pathology assessments of morbidity or mortality in GEMs and NOD mice (as well as in other experimental animals) offer quality assurance to the users and aim to identify conditions that can affect production and complicate research by affecting data and conclusions. Such reports can be found mainly as descriptive studies and they contribute to the data on spontaneous or background findings in a strain or “model” and enhance its value in research. In this context, an accurate definition of strain-specific pathology in those inbred mice that are most frequently used in biomedical research (especially for the generation of genetically engineered mice) is crucial to understand whether a phenotype results from the experimental intervention or rather reflects a naturally occurring entity. In the last few years, several studies and review articles dealing with this topic have been published. Therefore, for the purpose of this lecture, selected examples of expected pathology phenotypes and causes or contributors to death will be presented, particularly for strains such as C57BL/6, 129, and FVB/N because of their current relevance and ubiquity in the backgrounds of genetically engineered mice. Also, NSG and NOG mice, which represent the „gold standard“ host for xenotransplantation experiments, in recent years has become a popular tool in research. For these strains also will be shown examples of spontaneous infections, spontaneous post-transplant disorders and pathology of aging.

mice, GEM, NOD, spontaneous pathology, aging

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