Napredna pretraga

Pregled bibliografske jedinice broj: 962971

Neck adipose tissue - Tying ties in metabolic disorders

Pandzic Jaksic, Vlatka; Grizelj, Danijela; Livun, Ana; Boscic, Drago; Ajduk, Marko; Kusec, Rajko; Jaksic, Ozren
Neck adipose tissue - Tying ties in metabolic disorders // Hormone Molecular Biology and Clinical Investigation, 33 (2018), 2; 20170075, 9 doi:https://.org/10.1515/hmbci-2017-0075 (međunarodna recenzija, pregledni rad, znanstveni)

Neck adipose tissue - Tying ties in metabolic disorders

Pandzic Jaksic, Vlatka ; Grizelj, Danijela ; Livun, Ana ; Boscic, Drago ; Ajduk, Marko ; Kusec, Rajko ; Jaksic, Ozren

Hormone Molecular Biology and Clinical Investigation (1868-1891) 33 (2018), 2; 20170075, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Adipose tissue, brown, neck, perivascular, subcutaneous

Upper body adipose tissue accumulation has been associated with clustering of metabolic disorders and increased cardiovascular risk. Neck circumference (NC) indicated that subcutaneous adipose tissue (SAT) in that region is an independent pathogenic depot that might account for the additional risk missed by visceral adipose tissue (VAT). Neck adipose tissue (NAT) is not only one more ectopic depot but has several particular features that might modulate its metabolic role. Besides a controversial impact on obstructive apnea syndrome, neck fat encompasses carotid arteries as an important perivascular adipose tissue (PVAT) depot. With dysfunctional changes in obesity, physiologic vascular regulation is lost and inflammatory signals accelerate atherogenesis. Unexpected was the discovery of brown and beige adipocytes in the neck of human adults. When stimulated, brown adipose tissue (BAT) dissipates energy through thermogenesis and it is associated with other favorable metabolic effects. Moreover, the neck is the region where the browning mechanism was disclosed. With this unique plastic nature, NAT revealed multiple ties, challenging dynamics and potential new therapeutic targets that might have significant implications on metabolic outcomes and vascular risk.

Izvorni jezik

Znanstvena područja
Kliničke medicinske znanosti


Časopis indeksira:

  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
  • Scopus