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Pregled bibliografske jedinice broj: 962739

Relationship Between Dabigatran Concentrations in Plasma and Results of Routine Coagulation Assays PT, APTT, TT and Fibrinogen


Margetić, Sandra; Bronić, Ana; Ćelap, Ivana; Vuga, Ivana
Relationship Between Dabigatran Concentrations in Plasma and Results of Routine Coagulation Assays PT, APTT, TT and Fibrinogen // Research and Practice in Thrombosis and Haemostasis / Cushman, Mary (ur.).
Medford: Wiley Periodicals, 2018. str. 226-226 doi:10.1002/rth2.12125 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Relationship Between Dabigatran Concentrations in Plasma and Results of Routine Coagulation Assays PT, APTT, TT and Fibrinogen
(Relationship Between Dabigtran Concentrations in Plasma and Results of Routine Coagulation Assays PT, APTT, TT and Fibrinogen)

Autori
Margetić, Sandra ; Bronić, Ana ; Ćelap, Ivana ; Vuga, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Research and Practice in Thrombosis and Haemostasis / Cushman, Mary - Medford : Wiley Periodicals, 2018, 226-226

Skup
64th Annual ISTH SSC meeting

Mjesto i datum
Dublin, Irska, 18-21.07.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Dabigratan, PT, aPTT, TT

Sažetak
Background: Routine coagulation tests prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen are affected by dabigatran therapy, but are not standardized for assessment of its anticoagulant effect. However, exact knowledge of its impact on routine coagulation tests is a precondition for their correct interpretation. Aims: To assess relationship between dabigatran concentrations and results of routine coagulation assays. Methods: The study included 43 patients on dabigatran therapy. Plasma dabigatran concentrations were determined with DTI Innovance assay (Siemens, Germany) as a part of Croatian Science Foundation project HRZZ-IP- 2016-06-8208. All coagulation assays were determined on BCSXP analyzer using commercial reagents (Table 1). Results: Dabigatran plasma concentrations ranged from 22 to 401 ng/mL (median 101 ng/mL ; 95%CI 59-157 ng/mL). TT was unmeasurable (>150 s) in all patients with dabigatran levels above 100 ng/ml with significantly higher (P<0.0001) dabigatran levels compared to patients with TT<150s (median 69s). Among all patients, 16/43=0.37 had PT and 5/43=0.12 had APTT results in the reference range while 27/43=0.63 and 38/43=0.88 had prolonged PT and APTT, respectively. PT, APTT and fibrinogen were significantly different between patients with dabigatran levels below and above 100 ng/mL (Table 1). Conclusions: The results of routine coagulation tests are strongly dependent on dabigatran plasma concentrations. Due to its high sensitivity, TT could be useful for detecting minimal dabigatran levels in plasma, but is too sensitive for dabigatran levels above 100 ng/mL. PT lacks sensitivity in detecting therapeutic levels of dabigatran but neither the APTT was invariably prolonged in patients with dabigatran levels below 100 ng/mL. In summary, routine coagulation tests PT, APTT and TT, although dependent on dabigatran concentrations, could not be used to assess therapeutic response to dabigatran therapy through a wide range of its concentrations in plasma.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-8208 - Novi oralni antikoagulansi: povezanost koncentracije lijeka i antikoagulantnog učinka (LAB-NOAC) (Margetić, Sandra, HRZZ - 2016-06) ( POIROT)

Ustanove:
KBC "Sestre Milosrdnice"

Profili:

Avatar Url Ivana Ćelap (autor)

Avatar Url Ana Bronić (autor)

Avatar Url Sandra Margetić (autor)

Citiraj ovu publikaciju

Margetić, Sandra; Bronić, Ana; Ćelap, Ivana; Vuga, Ivana
Relationship Between Dabigatran Concentrations in Plasma and Results of Routine Coagulation Assays PT, APTT, TT and Fibrinogen // Research and Practice in Thrombosis and Haemostasis / Cushman, Mary (ur.).
Medford: Wiley Periodicals, 2018. str. 226-226 doi:10.1002/rth2.12125 (poster, međunarodna recenzija, sažetak, znanstveni)
Margetić, S., Bronić, A., Ćelap, I. & Vuga, I. (2018) Relationship Between Dabigatran Concentrations in Plasma and Results of Routine Coagulation Assays PT, APTT, TT and Fibrinogen. U: Cushman, M. (ur.)Research and Practice in Thrombosis and Haemostasis doi:10.1002/rth2.12125.
@article{article, editor = {Cushman, M.}, year = {2018}, pages = {226-226}, DOI = {10.1002/rth2.12125}, keywords = {Dabigratan, PT, aPTT, TT}, doi = {10.1002/rth2.12125}, title = {Relationship Between Dabigatran Concentrations in Plasma and Results of Routine Coagulation Assays PT, APTT, TT and Fibrinogen}, keyword = {Dabigratan, PT, aPTT, TT}, publisher = {Wiley Periodicals}, publisherplace = {Dublin, Irska} }
@article{article, editor = {Cushman, M.}, year = {2018}, pages = {226-226}, DOI = {10.1002/rth2.12125}, keywords = {Dabigratan, PT, aPTT, TT}, doi = {10.1002/rth2.12125}, title = {Relationship Between Dabigtran Concentrations in Plasma and Results of Routine Coagulation Assays PT, APTT, TT and Fibrinogen}, keyword = {Dabigratan, PT, aPTT, TT}, publisher = {Wiley Periodicals}, publisherplace = {Dublin, Irska} }

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