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Pregled bibliografske jedinice broj: 962176

Naphthoxazoles and heterobenzoxazoles : cholinesterase inhibiting and antioxidant activity


Šagud, Ivana; Škorić, Irena; Burčul, Franko
Naphthoxazoles and heterobenzoxazoles : cholinesterase inhibiting and antioxidant activity // Turkish journal of chemistry, 43 (2019), 118-124 doi:10.3906/kim-1807-133 (međunarodna recenzija, članak, znanstveni)


Naslov
Naphthoxazoles and heterobenzoxazoles : cholinesterase inhibiting and antioxidant activity

Autori
Šagud, Ivana ; Škorić, Irena ; Burčul, Franko

Izvornik
Turkish journal of chemistry (1300-0527) 43 (2019); 118-124

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antioxidant activity, cholinesterase activity, naphthoxazoles, fused heterobenzoxazoles

Sažetak
Finding novel cholinesterase inhibitors that would be able to cross the blood brain barrier, have favourable pharmacokinetic parameters and reduce hepatotoxicity along with other side- effects, has been the main focus of investigations dealing with Alzheimer’s disease. In this study we evaluated cholinesterase inhibitory and antioxidant activity of seven oxazole derivatives. These compounds have been efficiently and sustainably prepared by photochemical electrocyclization reaction. Various naphthoxazoles have been previously investigated as potential antibacterial, antituberculosis, and anticancer agents. They have also been tested for antioxidant activity, but never for cholinesterase inhibitory activity. Among the tested oxazole derivatives, fused heterobenzoxazole compounds with the pyridine and tiophene moiety, oxazolo[5, 4- h]isoquinoline, thieno[2', 3':5, 6]benzo[1, 2- d]oxazole and thieno[3', 2':5, 6]benzo[1, 2- d]oxazole showed the greatest potential for both the cholinesterase inhibitory and antioxidant activity. Among them the thieno[2', 3':5, 6]benzo[1, 2-d]oxazole was found to be the best one.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-6897 - Istraživanje bioaktivnih spojeva iz dalmatinskogbilja: njihov antioksidacijski karakter i utjecaj na enzimsku inhibiciju i zdravlje (Mladen Miloš, )

Ustanove
Kemijsko-tehnološki fakultet, Split,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Citiraj ovu publikaciju

Šagud, Ivana; Škorić, Irena; Burčul, Franko
Naphthoxazoles and heterobenzoxazoles : cholinesterase inhibiting and antioxidant activity // Turkish journal of chemistry, 43 (2019), 118-124 doi:10.3906/kim-1807-133 (međunarodna recenzija, članak, znanstveni)
Šagud, I., Škorić, I. & Burčul, F. (2019) Naphthoxazoles and heterobenzoxazoles : cholinesterase inhibiting and antioxidant activity. Turkish journal of chemistry, 43, 118-124 doi:10.3906/kim-1807-133.
@article{article, year = {2019}, pages = {118-124}, DOI = {10.3906/kim-1807-133}, keywords = {antioxidant activity, cholinesterase activity, naphthoxazoles, fused heterobenzoxazoles}, journal = {Turkish journal of chemistry}, doi = {10.3906/kim-1807-133}, volume = {43}, issn = {1300-0527}, title = {Naphthoxazoles and heterobenzoxazoles : cholinesterase inhibiting and antioxidant activity}, keyword = {antioxidant activity, cholinesterase activity, naphthoxazoles, fused heterobenzoxazoles} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • CA Search (Chemical Abstracts)
  • FSTA: Food Science and Technology Abstracts


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