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Pregled bibliografske jedinice broj: 961446

Hedgehog signaling pathway status in serous ovarian carcinomas


(College of Medicine, Qatar University, Doha, Qatar) Karin, Valentina; Slavica, Matea; Skrtic, Anita; Vranic, Semir; Serman, Ljiljana
Hedgehog signaling pathway status in serous ovarian carcinomas // Modern Pathology, USCAP 2018 Abstracts: Gynecologic and Obstetric Pathology (1127–1316)
Vancouver: Springer Nature, 2018. str. 428-429 doi:10.1038/modpathol.2018.11 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Hedgehog signaling pathway status in serous ovarian carcinomas

Autori
Karin, Valentina ; Slavica, Matea ; Skrtic, Anita ; Vranic, Semir ; Serman, Ljiljana

Kolaboracija
College of Medicine, Qatar University, Doha, Qatar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Modern Pathology, USCAP 2018 Abstracts: Gynecologic and Obstetric Pathology (1127–1316) / - Vancouver : Springer Nature, 2018, 428-429

Skup
USCAP Annual Meeting 2018

Mjesto i datum
Vancouver, Kanada, 17-23.03.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ovarian carcinoma ; Serous ovarian carcinoma ; Hedgehog signaling pathway ; PTCH1 ; GLI1 ; GLI3

Sažetak
Background: Hedgehog (Hh) signaling pathway is a highly conserved signaling pathway involved in cell proliferation and differentiation as well in cell polarity in early embryogenesis and morphogenesis. In adults, it is usually inactive while its hyperactivation is associated with carcinogenesis. Hh signaling pathway is activated via binding of the Hh ligands with PTCH transmembrane protein resulting in increased activity of the GLI transcription factors that subsequently activate targeted genes. PTCH1 acts as a tumor suppressor while GLI1 and GLI3 factors have the opposite transcription activities (former has activating and later mainly inhibiting activity). Design: Formalin-fixed paraffin- embedded samples of 52 ovarian serous carcinomas (low-grade [LGSC, n=11] and high-grade [HGSC, n=41]) were explored for PTCH1, GLI1 and GLI3 expression using immunohistochemistry. PTCH1 DNA methylation status was assessed using methylation- specific PCR assay (MSP). Five normal/benign ovarian tissues served as controls. Results: PTCH1 nuclear expression was significantly higher in both LGSC and HGSC compared with normal/benign ovarian tissue (p<0.001 and p<0.001, respectively) while cytoplasmic PTCH1 protein expression was significantly higher in normal ovaries compared with both LGSC and HGSC (p=0.003 and p<0.001, respectively). PTCH1 DNA methylation was exclusively observed in HGSC (6/41, 15%). GLI1 protein expression was significantly higher in HGSC compared with normal ovaries (p=0.032) while GLI3 protein exhibited significantly higher expression in both LGSC and HGSC in comparison with normal ovaries (p<0.001 and p<0.001, respectively). Notably, GLI3 protein had a higher expression in LGSC compared with HGSC (p=0.043). Conclusion: Hedgehog signaling pathway components PTCH1, GLI1 and GLI3 appear to be actively involved in pathogenesis of serous ovarian carcinomas. A significant proportion of serous ovarian carcinomas exhibits aberrant (nuclear) PTCH1 protein expression. Therefore, PTCH1 may play an active transcriptional role in LGSC and HGSC. A subset of HGSC may have PTCH1 gene deregulation caused by its promoter methylation. Further studies involving more samples should confirm these findings and their clinical relevance.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

(College of Medicine, Qatar University, Doha, Qatar) Karin, Valentina; Slavica, Matea; Skrtic, Anita; Vranic, Semir; Serman, Ljiljana
Hedgehog signaling pathway status in serous ovarian carcinomas // Modern Pathology, USCAP 2018 Abstracts: Gynecologic and Obstetric Pathology (1127–1316)
Vancouver: Springer Nature, 2018. str. 428-429 doi:10.1038/modpathol.2018.11 (poster, međunarodna recenzija, sažetak, znanstveni)
(College of Medicine, Qatar University, Doha, Qatar) (College of Medicine, Qatar University, Doha, Qatar) Karin, Valentina, Slavica, M., Skrtic, A., Vranic, S. & Serman, L. (2018) Hedgehog signaling pathway status in serous ovarian carcinomas. U: Modern Pathology, USCAP 2018 Abstracts: Gynecologic and Obstetric Pathology (1127–1316) doi:10.1038/modpathol.2018.11.
@article{article, author = {Karin, Valentina and Slavica, Matea and Skrtic, Anita and Vranic, Semir and Serman, Ljiljana}, year = {2018}, pages = {428-429}, DOI = {10.1038/modpathol.2018.11}, keywords = {Ovarian carcinoma, Serous ovarian carcinoma, Hedgehog signaling pathway, PTCH1, GLI1, GLI3}, doi = {10.1038/modpathol.2018.11}, title = {Hedgehog signaling pathway status in serous ovarian carcinomas}, keyword = {Ovarian carcinoma, Serous ovarian carcinoma, Hedgehog signaling pathway, PTCH1, GLI1, GLI3}, publisher = {Springer Nature}, publisherplace = {Vancouver, Kanada} }
@article{article, author = {Karin, Valentina and Slavica, Matea and Skrtic, Anita and Vranic, Semir and Serman, Ljiljana}, year = {2018}, pages = {428-429}, DOI = {10.1038/modpathol.2018.11}, keywords = {Ovarian carcinoma, Serous ovarian carcinoma, Hedgehog signaling pathway, PTCH1, GLI1, GLI3}, doi = {10.1038/modpathol.2018.11}, title = {Hedgehog signaling pathway status in serous ovarian carcinomas}, keyword = {Ovarian carcinoma, Serous ovarian carcinoma, Hedgehog signaling pathway, PTCH1, GLI1, GLI3}, publisher = {Springer Nature}, publisherplace = {Vancouver, Kanada} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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