Resorcylic acid lactones in urine samples of Croatian farm animals (CROSBI ID 255292)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vulić, Ana ; Lešić, Tina ; Kudumija, Nina ; Mikuš, Tomislav ; Pleadin, Jelka
engleski
Resorcylic acid lactones in urine samples of Croatian farm animals
Metabolic transformation of zearalenone (ZEA), a mycotoxin which can contaminate both food and feed, results in the formation of 5 metabolites, one of them being zeranol, which can be abused in farm animals as a growth promoter. To the best of our knowledge, there is no analytical method that can distinguish whether zeranol is present in an animal urine sample as a result of ZEA biotransformation or as a result of anabolic abuse. This study aimed at monitoring resorcylic acid lactones (RALs) concentration in urine of farm animals over several years. Six hundred and three cattle and pig urine samples were collected on farms in different Croatian regions and analysed for RAL presence. Based on the testing results all RAL- positive samples were considered to be consequential to feed contamination. The difference in primary ZEA metabolites’ ratio (α-zearalenol/ β-zearalenol) was observed between cattle (0.03-0.41) and pig (2.05-17.39) urine samples. If the animals are treated with zeranol and fed on ZEA-contaminated feed, zeranol and taleranol found in their organisms could come from two sources, so that the reliability of the statistical model might be questionable. Based on these findings, there exists the need for improving the approach to the distinction between zeranol abuse and ZEA feed contamination.
resorcyclic acid lactones, urine, cattle animals, pigs, LC-MS-MS
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Podaci o izdanju
43 (2)
2019.
126-133
objavljeno
0146-4760
1945-2403
10.1093/jat/bky069
Povezanost rada
Veterinarska medicina, Biotehnologija, Prehrambena tehnologija