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Pregled bibliografske jedinice broj: 958719

Specific zonal lipid accumulation in the liver of elderly rats on HFHS diet treated with Metformin and Liraglutide


(Department of Pharmacodynamics and Biopharmacy, University of Szeged, Hungary ; International Research and Innovation in Medicine Program, Ceders-Sinai Medical Center ; LA, USA) Blažetić, Senka; Zjalić, Milorad; Labak, Irena; Ivić, Vedrana; Imširović, Alen; Gaspar, Robert; Vari, G Sandor; Heffer, Marija
Specific zonal lipid accumulation in the liver of elderly rats on HFHS diet treated with Metformin and Liraglutide // Programme and Book of abstracts
Siofok, 2018. str. 229-229 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Specific zonal lipid accumulation in the liver of elderly rats on HFHS diet treated with Metformin and Liraglutide

Autori
Blažetić, Senka ; Zjalić, Milorad ; Labak, Irena ; Ivić, Vedrana ; Imširović, Alen ; Gaspar, Robert ; Vari, G Sandor ; Heffer, Marija

Kolaboracija
Department of Pharmacodynamics and Biopharmacy, University of Szeged, Hungary ; International Research and Innovation in Medicine Program, Ceders-Sinai Medical Center ; LA, USA

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Programme and Book of abstracts / - Siofok, 2018, 229-229

ISBN
978-615-5270-47-5

Skup
FEBS3+ conference

Mjesto i datum
Siofok, Hungary, 2-5.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Liver, Lipid accumulation, Obesity, Rat, Hepatic acinus

Sažetak
Liver has major role in fat and carbohydrates metabolism and it is one of the organs where the accumulation ectopic fat is taking place. Lipid accumulation in the liver promotes systematic metabolic dysfunction. In this study we analysed lipid accumulation based on functional organisation of liver parenchyma. Study included male and female Sprague-Dawley rats divided in 4 groups: 1. Standard diet (SD), 2. Diet rich in carbohydrates and fat (HFHSD), 3. HFHSD + metformin treatment and 4. HFHSD + liraglutide treatment. The experiment lasted for 20 weeks. Two different methods used to analyse lipid stores in the liver: Sudan black B stain for all lipids and Oil Red O for neutral lipids and fatty acids. There is sex specific pattern of lipid accumulation in the liver, HFHSD significantly increased lipid accumulation only in male rats. The lipid accumulation was less with Liraglutide and metformin. In male rats with HFHSD lipids accumulated with the same intensity in whole liver parenchyma, while in female group accumulation is dominant in peripheral part of the liver. This finding could be related to estrogen protective effect against hepatic fat accumulation by promoting insulin activity on glucose metabolism and limiting hepatic lipid deposition since elderly female rats still produce estrogen. Based on the hepatic acinus functional model the lipid accumulation in the liver is sex specific and zonal (peripheral and central). Funding: The study has been funded by RECOOP HST grant, and in part by the Croatian Science Foundation under project number IP-09-2014- 2324.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Osijek,
Sveučilište u Osijeku - Odjel za biologiju