hrvatski

Is there evidence for anti-inflammatory effect of hyperbaric oxygenation?

Hyperbaric oxygenation (HBO2) implies the administration of 100% oxygen at pressures greater than 1.4 atmosphere absolute in a series of treatments. Beside its primary use for the management of decompression sickness, HBO2 has been widely used method for the treatment of chronic wounds and with increasing number of newly established medical indications including stroke, inflammatory bowel disease, meningococcal sepsis, carbon monoxide poisoning, radiation injury, autism, glaucoma, prevention of postoperative cognitive dysfunction via preoperative preconditioning, sudden deafness etc. Many indications are based on positive clinical outcomes and experiences, while the precise mechanisms underlying its beneficial effects are only partially understood. Except for the increased supply of oxygen to the tissues deprived of O2, HBO2 is capable of inducing neo-vascularization through increased production of VEGF and mobilization of stem cells/endothelial progenitor cells. Recent study by Misir et al has demonstrated potential of HBO2 to reduce the infarct volume and improve cerebral blood flow after ischemic stroke by modifying levels of epoxyeicosatrienoic acid (EETs) in the vascular wall. Investigations of our lab have also made contribution to the understanding of anti- inflammatory effect of HBO2 in DSS-induced colitis in mice, which is at least partly dependent on expression of HIF-1α and antioxidative genes. Here we propose that the hyperbaric oxygenation has the potency to drive the pro-inflammatory immune response towards the anti-inflammatory/regulatory response via modulation of the hypoxia inducible factor 1alpha.

hyperbaric oxygenation ; inflammation

nije evidentirano