engleski

A computational study on influence of microstructure on wall stress distribution on 3D reconstructed model of human intracranial aneurysm

Intracranial aneurysm (IA) is a ‘ballooning’ of the vascular lumen of an intracranial artery that occurs most frequently at the branching points of the major arteries. Aneurysm rupture is believed to occur when the wall stress exceeds the strength of the wall tissue. Therefore, knowledge of the stress distribution in an intact IA wall could be valuable in assessing its risk of rupture. Finite element method is useful tool for noninvasive estimation the in vivo wall stress distribution for patient-specific IAs. However, microstructure of aneurysmal wall has been shown to vary among patients. While all IA walls are characterized by lack of elastic lamina, some of the IA walls had plenty of disorganized mural cells, whereas some of the walls had lost most of them [1]. For that reason, in this study we investigate possible physiological ranges of wall stress distribution of human intracranial aneurysm depending wall microstructure, as well as the role of active stress from smooth muscle cells (SMCs).

Intracranial aneurysm, Smooth muscle cells, Stress analysis

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