Effect of atopic skin stressors on natural moisturizing factors and cytokines in healthy adult epidermis (CROSBI ID 255039)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Engebretsen, K.A. ; Kezic, S. ; Jakaša, Ivone ; Hedengran, A. ; Linneberg, A. ; Skov, L. ; Johansen, J.D. ; Thyssen, J.P.
engleski
Effect of atopic skin stressors on natural moisturizing factors and cytokines in healthy adult epidermis
Background Epidermal deficiency of filaggrin, and the derived natural moisturizing factors (NMFs), is associated with increased risk of atopic dermatitis (AD). While filaggrin gene mutations cause filaggrin deficiency, there is limited insight into the causative environmental factors. Objectives To explore the effect of selected exogenous skin stressors on NMF and skin cytokine levels in healthy adult epidermis. Methods Forty healthy volunteers (aged 18–49 years) were exposed to hard, soft and chlorinated water, 05% sodium lauryl sulfate, house dust mite, cat allergen, staphylococcal enterotoxin B (SEB), cooling and histamine. Participants were tape- stripped and biophysiological measurements performed. NMF was determined after 24 and 48 h, whereas skin cytokines were measured after 24 h for selected exposures. Results At 24 h, a significant decrease in NMFs was observed for soft (051 019 g m2 h1) and hard water (061 032 g m2 h1) compared with occlusion alone (071 018 g m2 h1). Hard water led to increased levels of interleukin (IL)-4, interferon (IFN)-c and IL-10. Exposure to house dust mite and SEB led to a significant decrease in NMFs after 24 h (077 028 and 080 028 g m2 h1, respectively) compared with occlusion alone (100 042 g m2 h1). House dust mite led to an increase in IFN-c, IL-2 and IL-4 vs. the nonoccluded control site. Conclusions Based on experimental exposure to selected atopic skin stressors, we conclude that NMFs levels are decreased along with increased secretion of various skin cytokines in healthy individuals. Our data highlight environmental factors that might play a role in AD pathophysiology.
atopic skin stressors ; NMF ; cytokines ; stratum corneum ; TEWL ; water ; SLS
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
179 (3)
2018.
679-688
objavljeno
0007-0963
1365-2133
10.1111/bjd.16487