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Pregled bibliografske jedinice broj: 957385

Glomerular and tubular kidney damage markers in canine babesiosis caused by Babesia canis


Kuleš, Josipa; Bilić, Petra; Beer Ljubić, Blanka; Gotić, Jelena; Crnogaj, Martina; Brkljačić, Mirna; Mrljak, Vladimir
Glomerular and tubular kidney damage markers in canine babesiosis caused by Babesia canis // Ticks and Tick-Borne Diseases, 9 (2018), 6; 1508-1517 doi:10.1016/j.ttbdis.2018.07.012 (međunarodna recenzija, članak, znanstveni)


Naslov
Glomerular and tubular kidney damage markers in canine babesiosis caused by Babesia canis

Autori
Kuleš, Josipa ; Bilić, Petra ; Beer Ljubić, Blanka ; Gotić, Jelena ; Crnogaj, Martina ; Brkljačić, Mirna ; Mrljak, Vladimir

Izvornik
Ticks and Tick-Borne Diseases (1877-959X) 9 (2018), 6; 1508-1517

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Babesiosis ; kidney damage ; validation ; urinary markers ; kidney injury molecule -1 (KIM-1)

Sažetak
Canine babesiosis is a tick-borne disease caused by the haemoprotozoan parasites of the genus Babesia. The aim of this study was to assess renal dysfunction in dogs with babesiosis caused by B. canis, using serum and urinary markers for both glomerular and tubular dysfunction. Assays previously not validated for use in canine samples were validated and the potential interference of haemoglobin, lipids and bilirubin with these analyses was additionally considered. In this study 42 dogs naturally infected with B. canis and 14 healthy dogs were included. Dogs with babesiosis were divided into 3 groups: group A consisted of 9 non-azotemic dogs with normal urine protein to creatinine ratio (UPC < 0.5), group B of 27 non-azotemic dogs with UPC > 0.5 and group C of 6 azotemic dogs with UPC > 2. The concentrations of urinary immunoglobin G (IgG), retinol binding protein (RBP), uromodulin, kidney injury molecule – 1 (KIM-1), and serum symmetric dimethylarginine were measured by ELISA assays, while urinary albumin and N-acetyl-b-D- glucosaminidase (NAG) were evaluated by an immunoturbidimetric and enzymatic colorimetric assay, respectively. Urinary markers were normalized to urine creatinine concentration. All tested markers, with exception of uromodulin, showed significant differences between dogs with babesiosis and healthy dogs, and also showed strong or very strong positive correlation with UPC. Increases of urinary albumin and IgG suggested glomerular damage, and increases of KIM-1, RBP and NAG proximal tubular damage in dogs with babesiosis. They demonstrated clear advantages compared to conventional parameters by showing earlier changes in detecting renal damage.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina



POVEZANOST RADA


Projekt / tema
FP7 621394
HRZZ-IP-2013-11-4135 - Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasa (Vladimir Mrljak, )

Ustanove
Veterinarski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE
  • Zoological Record


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