engleski

The Effectiveness of Icariin on Biomarkers for Osteoporosis

Nutrition is important factor that influence bone metabolism, the endocrine and/or paracrine system, and bone-active mineral elements homeostasis. We studied antiosteoporetic effects of icariin and alendronate (ALN) in retinoic acid-induced (13cRA) bone loss in rats. Icariin has beneficial effects on bone health ; it improved the decrease in bone weight, the length and the diameter of the bone, calcium, and phosphorus content in bone ash, bone mineral density (BMD) and the biochemical markers of bone turnover and uterus atrophy induced by 13cRA. All result suggests that icariin reverses osteoporosis in 13cRA rats by stimulating bone formation or regulating bone resorption by its antioxidative and estrogenic-like activity without toxic-side effect observed in ALN treatment.

Icariin ; retinoic acid-induced bone loss ; rats ; bone markers

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