Droplet impact phenomena in fluidized bed coating process with a Wurster insert (CROSBI ID 254934)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Havaić, Tanja ; Đumbir, Ana-Maria ; Gretić, Matija ; Matijašić, Gordana ; Žižek, Krunoslav
engleski
Droplet impact phenomena in fluidized bed coating process with a Wurster insert
The aim of this study is to determine favorable process conditions for the coating of placebo tablets. Tablets made of microcrystalline cellulose are coated with hydroxypropyl cellulose polymer and Advantia™ Prime polymeric mixture film in lab-scale fluid-bed environment with a Wurster tube. In order to determine favorable process conditions (concentration, Wurster tube position, inlet air temperature, and atomization pressure), evaluation factors expressing process efficiency were calculated. Stereomicroscopy analysis provided good results with respect to the coating layer adherence and consistency. Results showed that the increased number of the coating cycles contributes to the desired featureless film morphology, when sufficiently high temperature and pressure are applied, thus resulting in high intra- and intertablet uniformity. Additionally, this paper analyzes the coating process from a mechanistic perspective of the underlying phenomena occurring on a tablet surface. Provided diagrams can help efficiently in detecting proper conditions that will result in coated tablets with strictly defined aimed properties. Process and formulation properties synergically result in a preferential occurrence of a deposition mechanism for all experiments conducted. Moreover, collision is found as a prevalent impact regime for the coating process studied. Finally, our intention here is to correlate hydrodynamic conditions and droplet breakup occurrence with a droplet diameter.
fluid bed ; Wurster insert ; coating
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Podaci o izdanju
2018
2018.
4546230
11
objavljeno
1687-806X
1687-8078
10.1155/2018/4546230
Povezanost rada
Kemijsko inženjerstvo