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Pregled bibliografske jedinice broj: 956926

Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)


Bačić, Ivan; Karlo, Robert; Zadro, Ana; Zadro, Zvonko; Skitarelić, Neven; Antabak, Anko
Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA) // Oncology Letters, 15 (2017), 1; 2335-2339 doi:10.3892/ol.2017.7576 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 956926 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)

Autori
Bačić, Ivan ; Karlo, Robert ; Zadro, Ana ; Zadro, Zvonko ; Skitarelić, Neven ; Antabak, Anko

Izvornik
Oncology Letters (1792-1074) 15 (2017), 1; 2335-2339

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
angiogenesis ; lung cancer ; micro vascular density

Sažetak
The aim of the present study was to evaluate angiogenesis by determining the micro vascular density (MVD) and the expression of vascular endothelial growth factor (VEGF-A) in advanced non-small cell lung cancer (NSCLC) tumor samples, and to analyze their associations with clinical parameters and survival. Tumor tissue specimens of fifty patients (41 males and 9 females), who underwent radical surgical treatment for NSCLC in stage IIIA (T1-3N2) were collected for immunohistochemical analysis. MVD evaluation was performed using an anti-CD31 monoclonal antibody and VEGF-A expression using a polyclonal anti-VEGF-A antibody. The results were associated with two-year survival. Statistical analysis revealed significant associations in the level of angiogenesis (high MVD) and shorter survival of patients with NSCLC (P=0.0007). VEGF-A expression showed no association with micro vascular density (P=0.51) or survival (P=0.68). There was no significant association between MVD and VEGF-A. The measurable, clinical MVD parameters could be used as a reliable prognostic factor for the survival of patients with advanced NSCLC.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove
Medicinski fakultet, Rijeka,
Opća bolnica Zadar,
Medicinski fakultet, Zagreb,
Sveučilište u Zadru

Profili:

Avatar Url Neven Skitarelić (autor)

Avatar Url Ivan Bačić (autor)

Avatar Url Robert Karlo (autor)

Avatar Url Anko Antabak (autor)

Avatar Url Zvonko Zadro (autor)

Citiraj ovu publikaciju

Bačić, Ivan; Karlo, Robert; Zadro, Ana; Zadro, Zvonko; Skitarelić, Neven; Antabak, Anko
Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA) // Oncology Letters, 15 (2017), 1; 2335-2339 doi:10.3892/ol.2017.7576 (međunarodna recenzija, članak, znanstveni)
Bačić, I., Karlo, R., Zadro, A., Zadro, Z., Skitarelić, N. & Antabak, A. (2017) Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA). Oncology Letters, 15 (1), 2335-2339 doi:10.3892/ol.2017.7576.
@article{article, year = {2017}, pages = {2335-2339}, DOI = {10.3892/ol.2017.7576}, keywords = {angiogenesis, lung cancer, micro vascular density}, journal = {Oncology Letters}, doi = {10.3892/ol.2017.7576}, volume = {15}, number = {1}, issn = {1792-1074}, title = {Tumor angiogenesis as an important prognostic factor in advanced non-small cell lung cancer (Stage IIIA)}, keyword = {angiogenesis, lung cancer, micro vascular density} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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