Application of chemical engineering methodology in process development: a case study of MenD-catalyzed synthesis of 6-cyano-4-oxohexanoic acid (CROSBI ID 254806)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Sudar, Martina ; Dejanović, Igor ; Müller, Michael ; Vasić-Rački, Đurđa ; Findrik Blažević, Zvjezdana
engleski
Application of chemical engineering methodology in process development: a case study of MenD-catalyzed synthesis of 6-cyano-4-oxohexanoic acid
To speed up evaluation, development and upscaling of new processes, the use of engineering methodology can have a great impact. Here we show the application of an engineering approach to find the reaction conditions allowing the best process metrics. An experimentally validated mathematical model for the MenD-catalyzed synthesis of a commercially unavailable product 6-cyano-4- oxohexanoic acid, with a potential industrial use as a building block, was used for process optimization. Using the optimized conditions, 62.4 g dm-3 of product, volume productivity of 87.1 g dm-3 d-1, product yield of 96 % and biocatalyst productivity of 25.8 kgP kgMenD-1 can be achieved. Based on the optimized production procedure, economic analysis was performed to determine minimal product price required for project to be profitable in 8 years economic lifetime. In addition, Monte Carlo analysis (MCA) was used to assess the influence of uncertainties in estimation of input variables on overall economic performance.
mathematical modeling ; process economics ; Monte Carlo analysis ; C-C coupling ; enzyme catalysis ; process engineering
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Podaci o izdanju
32 (4)
2018.
501-510
objavljeno
0352-9568
1846-5153
10.15255/CABEQ.2018.1393
Povezanost rada
Biotehnologija, Kemijsko inženjerstvo