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Pregled bibliografske jedinice broj: 956310

Chloroquine urea derivatives: synthesis and antitumor activity in vitro


Pavić, Kristina; Rajić, Zrinka; Mlinarić, Zvonimir; Uzelac, Lidija; Kralj, Marijeta; Zorc, Branka
Chloroquine urea derivatives: synthesis and antitumor activity in vitro // Acta pharmaceutica, 68 (2018), 4; 471-483 doi:10.2478/acph-2018-0039 (međunarodna recenzija, članak, znanstveni)


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Naslov
Chloroquine urea derivatives: synthesis and antitumor activity in vitro

Autori
Pavić, Kristina ; Rajić, Zrinka ; Mlinarić, Zvonimir ; Uzelac, Lidija ; Kralj, Marijeta ; Zorc, Branka

Izvornik
Acta pharmaceutica (1330-0075) 68 (2018), 4; 471-483

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chloroquine ; Hydroxychloroquine ; Urea ; Antitumor activity in vitro

Sažetak
In the current paper, we describe the design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4–10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide an insight into the design of new anticancer agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-1501 - Dizajniranje, sinteza i evaluacija derivata primakina, vorinostata i sorafeniba kao potencijalnih citostatika (HRZZ)
HRZZ-IP-2013-11-5660 - Mulitidisciplinarni pristup otkriću lijekova s ciljanim djelovanjem na matične stanice tumora – uloga transporta kalija (Marijeta Kralj, HRZZ)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marijeta Kralj (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Lidija Uzelac (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Kristina Pavić (autor)

Citiraj ovu publikaciju

Pavić, Kristina; Rajić, Zrinka; Mlinarić, Zvonimir; Uzelac, Lidija; Kralj, Marijeta; Zorc, Branka
Chloroquine urea derivatives: synthesis and antitumor activity in vitro // Acta pharmaceutica, 68 (2018), 4; 471-483 doi:10.2478/acph-2018-0039 (međunarodna recenzija, članak, znanstveni)
Pavić, K., Rajić, Z., Mlinarić, Z., Uzelac, L., Kralj, M. & Zorc, B. (2018) Chloroquine urea derivatives: synthesis and antitumor activity in vitro. Acta pharmaceutica, 68 (4), 471-483 doi:10.2478/acph-2018-0039.
@article{article, year = {2018}, pages = {471-483}, DOI = {10.2478/acph-2018-0039}, keywords = {Chloroquine, Hydroxychloroquine, Urea, Antitumor activity in vitro}, journal = {Acta pharmaceutica}, doi = {10.2478/acph-2018-0039}, volume = {68}, number = {4}, issn = {1330-0075}, title = {Chloroquine urea derivatives: synthesis and antitumor activity in vitro}, keyword = {Chloroquine, Hydroxychloroquine, Urea, Antitumor activity in vitro} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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