Chloroquine urea derivatives: synthesis and antitumor activity in vitro (CROSBI ID 254798)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Pavić, Kristina ; Rajić, Zrinka ; Mlinarić, Zvonimir ; Uzelac, Lidija ; Kralj, Marijeta ; Zorc, Branka
engleski
Chloroquine urea derivatives: synthesis and antitumor activity in vitro
In the current paper, we describe the design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4–10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide an insight into the design of new anticancer agents.
Chloroquine ; Hydroxychloroquine ; Urea ; Antitumor activity in vitro
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Podaci o izdanju
Trošak objave rada u otvorenom pristupu
Povezanost rada
Kemija, Temeljne medicinske znanosti, Farmacija