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AMINO SUBSTITUTED BENZAMIDE DERIVATIVES AS POTENTIAL ANTIOXIDANTS


Perin, Nataša; Hranjec, Marijana; Roškarić, Petra; Sović, Irena; Boček, Ida; Vianello, Robert; Starčević, Kristina
AMINO SUBSTITUTED BENZAMIDE DERIVATIVES AS POTENTIAL ANTIOXIDANTS // Book of Abstracts, 17th Ružička days "Today science-tomorrow industry", Vukovar, Hrvatska, 19.-21.09.2018. / Tomas, Srećko ; Ačkar, Đurđica (ur.).
Zagreb: PTF, HDKI, 2018. str. 27-27 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
AMINO SUBSTITUTED BENZAMIDE DERIVATIVES AS POTENTIAL ANTIOXIDANTS

Autori
Perin, Nataša ; Hranjec, Marijana ; Roškarić, Petra ; Sović, Irena ; Boček, Ida ; Vianello, Robert ; Starčević, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts, 17th Ružička days "Today science-tomorrow industry", Vukovar, Hrvatska, 19.-21.09.2018. / Tomas, Srećko ; Ačkar, Đurđica - Zagreb : PTF, HDKI, 2018, 27-27

ISBN
978-953-6894-65-9

Skup
17th Ružiča days "Today science-tomorrow industry"

Mjesto i datum
Vukovar, Hrvatska, 19-21.09.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Benzamide derivatives, antioxidative potential, computational study

Sažetak
In the last few decades, the search for the novel antioxidants led to the synthesis or isolation of different organic molecules which showed promising and more effective antioxidant activity in comparison with the standard antioxidants, such as vitamins C and A or BHT[1]. We prepared a range of N-arylbenzamides with a variable number of methoxy and hydroxy groups, bearing either amino or amino protonated moieties, and used DPPH and FRAP assays to evaluate their antioxidant capacity[2]. Most of the systems exhibit improved antioxidative properties relative to the reference BHT molecule in both assays. Combining results from both sets of experiments, the most promising antioxidative potential was displayed by the trihydroxy derivative, which we propose as a lead compound for a further optimization of the benzamide scaffold. Computational analysis helped in interpreting the observed trends and demonstrated that protonated systems are better antioxidants than their neutral counterparts, while underlying the positive influence of the electron-donating methoxy group on the antioxidant properties, thus confirming the experiments. It also revealed that the introduction of the hydroxy groups shifts the reactivity from both amide and amine groups towards this moiety and additionally enhances antioxidative features.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-3386 - Dizajn i sinteza novih dušikovih heterocikličkih fluorofora i fluorescentnih nanomaterijala kao kemijskih senzora za pH i metalne ione (Robert Vianello, )

Ustanove
Veterinarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb