The effects of strawberry tree (Arbutus unedo L.) water leaf extract and arbutin upon kidney function and primary DNA damage in renal cells of rats (CROSBI ID 254767)
Prilog u časopisu | kratko priopćenje | međunarodna recenzija
Podaci o odgovornosti
Jurica, Karlo ; Benković, Vesna ; Sikirić, Sunčana ; Brčić Karačonji, Irena ; Kopjar, Nevenka
engleski
The effects of strawberry tree (Arbutus unedo L.) water leaf extract and arbutin upon kidney function and primary DNA damage in renal cells of rats
Although strawberry tree (Arbutus unedo L.) leaves have long been used as a herbal remedy, insufficient information is available on their nephrotoxicity. We assessed the safety of strawberry tree water leaf extract and its key component arbutin, administered per os to Lewis rats of both genders at 200 mg/kg b.w./day for 14 and 28 days. The effects of the tested compounds on DNA integrity in renal cells was evaluated using alkaline comet assay, while kidney function was studied using serum creatinine and urea levels. Strawberry tree water leaf extract showed high biocompatibility with kidney tissue. It did not impair DNA integrity of renal cells and kidney function, either in male or female rats. However, exposure to single arbutin affected the levels of primary DNA damage in renal cells which could be related to metabolic conversion of arbutin into hydroquinone, whose nephrotoxicity has previously been proven.
alkaline comet assay ; Arbutus unedo L. ; creatinine ; herbal product ; nephrotoxicity
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Podaci o izdanju
34 (16)
2020.
2354-2357
objavljeno
1478-6419
1478-6427
10.1080/14786419.2018.1534106
Povezanost rada
Biologija, Farmacija, Temeljne medicinske znanosti