engleski

BIOLOGICAL, ANTIOXIDANT AND CHOLINESTERASE INHIBITION ACTIVITY STUDIES ON NAPHTHO[1, 2-d]/[2, 1-d]OXAZOLES

Numerous 4/5-styryloxazoles were prepared and transformed into [1, 2/2, 1-d]-naphtooxazoles [1, 2] by reaction of photochemical cyclization. Naphtooxazoles are hard to synthesize by ground chemistry methods and we have described a first photochemical synthesis of these compounds [1]. All of the precursors as well as the final products are described by spectroscopic methods. After these compounds were synthesized they were further tested for biological activity, antioxidant properties [2] as well as metabolic stability [3]. Results of the bioassays as well the results for the antioxidant properties will be presented on the poster. They also proved to be potent acetyl- and butyryl-cholinesterase inhibitors and these results will also be given and interpreted on the poster. 1. I. Šagud, F. Faraguna, Ž. Marinić, M. Šindler-Kulyk, J. Org. Chem. 76 (2011) 2904- 2908. 2. Unpublished results. 3. Poster presentation from Vanja Kelava at 5th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS 2018)

antioxidant activity, biological activity, cholinesterase inhibition, activity, naphtho[1, 2-d]/[2, 1-d]oxazoles

nije evidentirano