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Pregled bibliografske jedinice broj: 955148

Luteolin exhibits cytotoxicity in human colorectal carcinoma SW620 cells through activation of MAPK and FOXO3a pathways


Potočnjak, Iva; Vukelić, Iva; Gobin, Ivana; Domitrović, Robert
Luteolin exhibits cytotoxicity in human colorectal carcinoma SW620 cells through activation of MAPK and FOXO3a pathways // Food and chemical toxicology (2019) (znanstveni, poslan)


Naslov
Luteolin exhibits cytotoxicity in human colorectal carcinoma SW620 cells through activation of MAPK and FOXO3a pathways

Autori
Potočnjak, Iva ; Vukelić, Iva ; Gobin, Ivana ; Domitrović, Robert

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Food and chemical toxicology (2019)

Status rada
Poslan

Ključne riječi
Colon cancer SW620 cells ; luteolin ; mitogen-activated protein kinase ; forkhead box O ; apoptosis ; autophagy

Sažetak
Luteolin, a natural phenolic compound, has been shown to possess numerous beneficial health effects, including anticancer. The aim of this study was to investigate the anticancer activity of luteolin in human colon carcinoma cells. Luteolin dose-dependently (0‒10 µM) reduced viability and proliferation of SW620 cells. The expression of Bcl-2 decreased whereas Bax, caspase-3, and poly (ADP-ribose) polymerase (PARP) increased by luteolin treatment, suggesting that luteolin was able to induce apoptosis in SW620 cells. Moreover, luteolin induced autophagy in the cancer cells by increasing expression of microtubule- associated protein 1A/1B-light chain 3 beta (LC3B), Atg7, and Beclin-1. Treatment with luteolin increased heme oxygenase (HO-1) and superoxide dismutase 2 (SOD2) expression, suggesting induction of oxidative stress as an underlying mechanism. The cytotoxic activity of luteolin coincided by activation of extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase 1/2 (JNK1/2), and p38, with co-induction of FOXO3a. Interestingly, the cytotoxic activity of luteolin was not associated with suppression of the Wnt/β-catenin pathway. The results of the current study suggest the cytotoxic but not antimetastatic activity of luteolin in human colon carcinoma SW620 cells through the MAPK and FOXO3a-dependent mechanism.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



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Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE