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Pregled bibliografske jedinice broj: 954250

A case of synthetic cannabinoid poisoning in Croatia


Sutlović, Davorka; Prkačin, Ingrid; Vaiano, Fabio; Bertol, Elisabetta; Veršić Bratinčević, Maja; Definis-Gojanović, Marija
A case of synthetic cannabinoid poisoning in Croatia // Arhiv za higijenu rada i toksikologiju, 69 (2018), 2; 186-190 doi:10.2478/aiht-2018-69-3100 (međunarodna recenzija, članak, stručni)


Naslov
A case of synthetic cannabinoid poisoning in Croatia

Autori
Sutlović, Davorka ; Prkačin, Ingrid ; Vaiano, Fabio ; Bertol, Elisabetta ; Veršić Bratinčević, Maja ; Definis-Gojanović, Marija

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 69 (2018), 2; 186-190

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
5F-AMB ; emergency medicine ; GC/MS analysis ; new psychoactive substances ; synthetic cannabinoids

Sažetak
The number of new psychoactive substances (NPS), synthetic cannabinoids (SCs) in particular, is growing constantly. Because of the insufficiently explored effects on consumer health, they have become a major problem in the emergency departments. They are difficult to identify, and there are no antidotes that could reverse their detrimental effects. We report a case of poisoning of a young man who used SCs. The patient was admitted to the emergency department of the Clinical Hospital Merkur, Zagreb (Croatia) after sniffing and smoking a herbal product bought on the street. He presented with severe cognitive difficulties and visible eye redness. Other symptoms included somnolence, disorientation, loss of coordination, unsteady gait, hyporeflexia, stiffness, cramps and cold limbs, blurred vision, teeth grinding, dry mouth, tinnitus, fear, suicidal thoughts, impaired focus, memory, and speech, sedation, fatigue, depression, thought blocking, and autistic behaviour. His skin was dry, and his mucosa dry and irritated. Herbal products “Rainbow Special” and “Luminated Aroma” used by the patient were qualitatively analysed with gas chromatography / mass spectrometry (GC/ MS) after direct extraction with an organic solvent. Solid-phase extraction method was used to analyse serum and urine samples. Despite the negative findings of biological samples, mostly due to the limitations of GC/MS, the clinical picture infallibly pointed to the poisoning with SCs. This was confirmed by the findings of 5-fluoro AMB (methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate) in the herbal products.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove
Klinička bolnica "Merkur",
KBC Split,
Medicinski fakultet, Split

Citiraj ovu publikaciju

Sutlović, Davorka; Prkačin, Ingrid; Vaiano, Fabio; Bertol, Elisabetta; Veršić Bratinčević, Maja; Definis-Gojanović, Marija
A case of synthetic cannabinoid poisoning in Croatia // Arhiv za higijenu rada i toksikologiju, 69 (2018), 2; 186-190 doi:10.2478/aiht-2018-69-3100 (međunarodna recenzija, članak, stručni)
Sutlović, D., Prkačin, I., Vaiano, F., Bertol, E., Veršić Bratinčević, M. & Definis-Gojanović, M. (2018) A case of synthetic cannabinoid poisoning in Croatia. Arhiv za higijenu rada i toksikologiju, 69 (2), 186-190 doi:10.2478/aiht-2018-69-3100.
@article{article, year = {2018}, pages = {186-190}, DOI = {10.2478/aiht-2018-69-3100}, keywords = {5F-AMB, emergency medicine, GC/MS analysis, new psychoactive substances, synthetic cannabinoids}, journal = {Arhiv za higijenu rada i toksikologiju}, doi = {10.2478/aiht-2018-69-3100}, volume = {69}, number = {2}, issn = {0004-1254}, title = {A case of synthetic cannabinoid poisoning in Croatia}, keyword = {5F-AMB, emergency medicine, GC/MS analysis, new psychoactive substances, synthetic cannabinoids} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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