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Pregled bibliografske jedinice broj: 953942

The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease


Babić, Ana; Osmanović Barilar, Jelena; Knezović, Ana; Bagarić, Robert; Farkaš, Vladimir; Riederer, Peter; Šalković-Petrišić, Melita
The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease // 11th FENS Forum of Neuroscience Abstracts
Berlin, Njemačka, 2018. str. 4102-4102 (poster, nije recenziran, sažetak, znanstveni)


CROSBI ID: 953942 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease

Autori
Babić, Ana ; Osmanović Barilar, Jelena ; Knezović, Ana ; Bagarić, Robert ; Farkaš, Vladimir ; Riederer, Peter ; Šalković-Petrišić, Melita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
11th FENS Forum of Neuroscience Abstracts / - , 2018, 4102-4102

Skup
11th FENS Forum of Neuroscience

Mjesto i datum
Berlin, Njemačka, 07-11.07.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Alzheimer's disease ; galactose ; metabolism ; trangenic mice ; cognition

Sažetak
AIMS: Decreased glucose metabolism and energy in the brain accompanies sporadic Alzheimer’s disease (sAD). Our recent research revealed that oral galactose, an alternative source of energy, successfully prevented the development/normalized early-developed cognitive deficits in a nontransgenic sAD rat model. We aimed to explore whether oral galactose has therapeutic effects on cognitive deficits in transgenic mice model of familial AD. METHODS: 80 male transgenic Tg2576 (WT/TG) and wild-type (WT/WT) mice aged 5 and 10 months underwent 2-month drink of oral galactose solution (+GAL) or tap water. Morris Water Maze (MWM), intraperitoneal glucose tolerance test, and fluorodeoxyglucose Positron-Emission- Tomography (PET) scanning were performed before sacrifice. RESULTS: MWM showed no deficits in 7-month but significant (p=0.029) cognitive decline in 12- month aged WT/TG mice compared to their respective WT/WT controls (-75%/probe trial) associated with markedly decreased movement pattern which worsened by galactose treatment in WT/WT and WT/TG groups. PET scans demonstrated increased (+19.65%) and decreased (-17.70%) glucose uptake/metabolism in the whole brain of 7- and 12-month aged WT/TG mice, which were normalized by galactose (decreased -13.90%/7-month and increased +32.09%/12-month aged WT/TG+GAL mice) respectively. Compared to WT/WT, WT/TG group showed impaired glucose tolerance only at 12- months (glucose level increased +16 to +72%) further worsened by galactose treatment (additional +21 to +51% increment, p<0.05). Galactose treatment had no effects in 12-month aged WT/WT group but lowered glucose levels in 7-month old group (-32 to -45%). CONCLUSION: Oral galactose worsens peripheral but improves central glucose homeostasis without affecting memory in cognitively impaired transgenic AD mice. Supported by HRZZ-IP-09-2014-4639.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-4639 - TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI (GALAD) (Melita Šalković, Petrišić, HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

mef.unizg.hr w3.kenes-group.com mef.unizg.hr

Citiraj ovu publikaciju:

Babić, Ana; Osmanović Barilar, Jelena; Knezović, Ana; Bagarić, Robert; Farkaš, Vladimir; Riederer, Peter; Šalković-Petrišić, Melita
The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease // 11th FENS Forum of Neuroscience Abstracts
Berlin, Njemačka, 2018. str. 4102-4102 (poster, nije recenziran, sažetak, znanstveni)
Babić, A., Osmanović Barilar, J., Knezović, A., Bagarić, R., Farkaš, V., Riederer, P. & Šalković-Petrišić, M. (2018) The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease. U: 11th FENS Forum of Neuroscience Abstracts.
@article{article, author = {Babi\'{c}, Ana and Osmanovi\'{c} Barilar, Jelena and Knezovi\'{c}, Ana and Bagari\'{c}, Robert and Farka\v{s}, Vladimir and Riederer, Peter and \v{S}alkovi\'{c}-Petri\v{s}i\'{c}, Melita}, year = {2018}, pages = {4102-4102}, keywords = {Alzheimer's disease, galactose, metabolism, trangenic mice, cognition}, title = {The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease}, keyword = {Alzheimer's disease, galactose, metabolism, trangenic mice, cognition}, publisherplace = {Berlin, Njema\v{c}ka} }
@article{article, author = {Babi\'{c}, Ana and Osmanovi\'{c} Barilar, Jelena and Knezovi\'{c}, Ana and Bagari\'{c}, Robert and Farka\v{s}, Vladimir and Riederer, Peter and \v{S}alkovi\'{c}-Petri\v{s}i\'{c}, Melita}, year = {2018}, pages = {4102-4102}, keywords = {Alzheimer's disease, galactose, metabolism, trangenic mice, cognition}, title = {The effect of oral galactose on glucose homeostasis and memory in a transgenic mice model of familial Alzheimer's disease}, keyword = {Alzheimer's disease, galactose, metabolism, trangenic mice, cognition}, publisherplace = {Berlin, Njema\v{c}ka} }




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