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MAGNESIUM SUBSTITUTED HYDROXYAPATITE SCAFFOLDS HYDROTHERMALLY SYNTHESIZED FROM CUTTLEFISH BONE

Hydroxyapatite (HAp, Ca10(PO4)6(OH)2) and magnesium substituted HAp scaffolds were hydrothermally synthesised from the cuttlefish bone. The compositional and morphological properties of the scaffold were studied by means of X-ray powder diffraction, FTIR spectroscopy, thermogravimetric analysis and scanning electron microscopy. Total conversion of aragonite to HAp was confirmed while original highly porous interconnected structure was preserved. The HAp structure was refined with Rietveld refinement and used as initial structure for magnesium substituted samples. As HAp can incorporate only a limited amount of Mg2+ into structure, whitlockite (WH, Ca18Mg2(HPO4)2(PO4)12) is formed from the Mg2+ excess. As analysis confirmed formation of nonstoichiometric AB-type carbonated HPO42- substituted HAp, main component of natural bone, and formation of magnesium rich WH phase, found in human body, synthesised scaffolds should have improved biological properties compared to synthetic stoichiometric HAp.

magnesium substituted hydroxyapatite, X-ray powder diffraction, Rietveld refinement method, whitlockite, scaffold, cuttlefish bone, hydrothermal synthesis

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