engleski

Synthesis of heterocyclic compounds with biological activity in deep eutectic solvents

Deep eutectic solvents(DESs)are novel generation of green solvents which have proven to be a convenient media for many synthetic routes. They are often characterized as environmentally friendly and sustainable mixtures of nontoxic and cheap components which are combined together from a eutectic mixture. Hydrogen bond acceptors (HBAs ; quaternary ammonium or metal salt) are often combined with hydrogen bond donors (HBDs ; amides, carboxylic acids, alcohols and sugars) in different ratios to obtain DES with desirable physical and chemical characteristics. Hereby, we describe our achievements in the field of heterocycle synthesis in DESs. So far, we have found DESs to be very effective in synthesis of novel coumarinyl Schiff bases, Knoevenagel condensation of rhodanine with aromatic aldehydes, synthesis of thiosemicarbazides and triazoles from isothiocyanates and coumarinyl hydrazide, synthesis of 2-mercaptoquinazolinones from anthranilic acid and isothiocyanates. At present, a screening of 20 different deep eutectic solvents has been carried out to determine a convenient DES and temperature for the synthesis of quinazoline derivatives from anthranilic or substituted anthranilic acid.

deep eutectic solvents, Knoevenagel condensation, rhodanine, quinazolinone

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