High prevalence of CYP2C19*17 allele in the Roma population from Croatia (CROSBI ID 664979)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Zajc Petranović, Matea ; Tomas, Željka ; Škarić-Jurić, Tatjana ; Smolej Narančić, Nina ; Janićijević, Branka ; Peričić Salihović, Marijana
engleski
High prevalence of CYP2C19*17 allele in the Roma population from Croatia
CYP2C19 gene is a member of cytochrome P450 family that codes for enzymes involved in the biotransformation of many endogenous and exogenous substances. Roma are a transnational minority population with numerous health problems, often treated with drugs metabolised by CYP2C19 enzyme. Ten CYP2C19 loci were genotyped in 440 Roma from Croatia, seven of which were monomorphic (rs28399504, rs4986893, rs55640102, rs56337013, rs72552267, rs72558186 and rs41291556). Minor allele frequency (MAF) of rs4244285 in the Roma population was 15.5%, similar to the surrounding Croatian population, and MAF of rs12248560 (CYP2C19*17) was 28.3%, higher not only compared to Croatian population, but also to other world populations. MAF of rs3758581 in the Croatian Roma was 18.3%, which is also notably higher than in other populations. Genetic profile of CYP2C19 in Croatian Roma might be the result of reproductive isolation and definitelly should be taken into account in prescribing drugs, to prevent adverse drug reactions.
ADME ; CYP2C19 ; pharmacogenetics ; Roma ; Croatia
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Podaci o prilogu
40-41.
2018.
objavljeno
Podaci o matičnoj publikaciji
Abstract Book EAA 2018
Podaci o skupu
21st Congress of the European Anthropological Association
predavanje
22.08.2018-25.08.2018
Odense, Danska