engleski

GLASSY CELL CARCINOMA OF THE ENDOMETRIUM: A CASE REPORT

Aims: We present a case of 65-year old patient with glassy cell carcinoma of the endometrium, which is a rare neoplasm. To our knowledge, there are 14 previously cases reported in the literature. Microscopically, it is composed of malignant cells showing a "ground glass" cytoplasm, large nuclei with prominent nucleoli and distinct cell membranes. Nature of glassy cell carcinoma is still debatable, for now it is considered to be a poorly differentiated variant of adenosquamous carcinoma Method: A 65-year-old patient with ultrasonically found thickened endometrium underwent hysteroscopy. Histologically the tumor showed polypoid solid mass of epithelilal cells with ground glass cytoplasm and large nuclei with prominent nucleoli. Immunohistochemical analysis confirmed diagnosis of glassy cell carcinoma of the endometrium. The patient underwent bilateral salpingo-oophorectomy, total abdominal hysterectomy and radiation therapy. Results: She is alive, with no evidence of disease for 14 months after diagnosis. Conclusion: There are no specific recommendations about treatment of this rare disease. Detailed analysis of more cases is required to evaluate the nature of glassy cell carcinoma and to determine accurate prognosis for this infrequent entity.

glass-cell carcinoma, endometrium

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