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Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets (CROSBI ID 254120)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Sabol, Maja ; Trnski, Diana ; Musani, Vesna ; Ozretić, Petar ; Levanat, Sonja Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets // International journal of molecular sciences, 19 (2018), 9; 2562, 37. doi: 10.3390/ijms19092562

Podaci o odgovornosti

Sabol, Maja ; Trnski, Diana ; Musani, Vesna ; Ozretić, Petar ; Levanat, Sonja

engleski

Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets

GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant activation in adult cells leads to carcinogenesis through overactivation of several tightly regulated cellular processes such as proliferation, angiogenesis, EMT. Targeting GLI transcription factors has recently become a major focus of potential therapeutic protocols.

HH-GLI signaling pathway ; GLI transcription factors ; signal transduction ; malformations ; cancer ; therapy

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Podaci o izdanju

19 (9)

2018.

2562

37

objavljeno

1422-0067

10.3390/ijms19092562

Trošak objave rada u otvorenom pristupu

Povezanost rada

Temeljne medicinske znanosti

Poveznice
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