Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets (CROSBI ID 254120)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Sabol, Maja ; Trnski, Diana ; Musani, Vesna ; Ozretić, Petar ; Levanat, Sonja
engleski
Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
GLI transcription factors have important roles in intracellular signaling cascade, acting as the main mediators of the HH-GLI signaling pathway. This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. The HH-GLI pathway is mostly inactive in the adult organism but retains its function in stem cells. Aberrant activation in adult cells leads to carcinogenesis through overactivation of several tightly regulated cellular processes such as proliferation, angiogenesis, EMT. Targeting GLI transcription factors has recently become a major focus of potential therapeutic protocols.
HH-GLI signaling pathway ; GLI transcription factors ; signal transduction ; malformations ; cancer ; therapy
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
19 (9)
2018.
2562
37
objavljeno
1422-0067
10.3390/ijms19092562
Trošak objave rada u otvorenom pristupu
Povezanost rada
Temeljne medicinske znanosti