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Pregled bibliografske jedinice broj: 951584

HIF-1—a big chapter in the cancer tale


Ajduković, Jasna
HIF-1—a big chapter in the cancer tale // Experimental oncology, 38 (2016), 1; 9-12 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 951584 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
HIF-1—a big chapter in the cancer tale

Autori
Ajduković, Jasna

Izvornik
Experimental oncology (0204-3564) 38 (2016), 1; 9-12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
adaptive cellular response, cancer stemness, hypoxia, hypoxia-inducible factor 1, tumor progression

Sažetak
Approximately 1.0–1.5% of the genome is transcriptionally regulated by hypoxia, and hypoxia-inducible factor (HIF)-1α is the transcription factor modulating many of these genes. Cancer cells are able to survive hypoxic environments and hypoxia itself can activate adaptive cellular responses that contribute to tumor progression. Many HIF-1α-mediated biological effects are beneficial for tumor progression, including metabolic shift toward glycolysis, inhibition of fatty acid β-oxidation, production of cellular reactive oxygen species and altering expression of tumor suppressor genes. HIF-1 promotes selective mitochondrial autophagy, resistance to T cell mediated lysis of cancer cells, induction of pluripotent cancer stem cells, epithelial-mesenchymal and epithelial-mesenchymal- endothelial transitions beneficial for tumor growth and progression, loss of E-cadherin. HIF-1 also induces production of signal molecules and cytokines by carcinoma-associated fibroblasts and upregulation of certain microRNAs important for cancer progression. This minireview focuses on the HIF-1 promoting role in tumor initiation and progression and HIF-1 targeting. HIF-1 pathway downregulation seems to be promising in future cancer treatment.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Profili:

Avatar Url Jasna Ajduković (autor)

Poveznice na cjeloviti tekst rada:

exp-oncology.com.ua

Citiraj ovu publikaciju:

Ajduković, Jasna
HIF-1—a big chapter in the cancer tale // Experimental oncology, 38 (2016), 1; 9-12 (međunarodna recenzija, pregledni rad, znanstveni)
Ajduković, J. (2016) HIF-1—a big chapter in the cancer tale. Experimental oncology, 38 (1), 9-12.
@article{article, author = {Ajdukovi\'{c}, Jasna}, year = {2016}, pages = {9-12}, keywords = {adaptive cellular response, cancer stemness, hypoxia, hypoxia-inducible factor 1, tumor progression}, journal = {Experimental oncology}, volume = {38}, number = {1}, issn = {0204-3564}, title = {HIF-1—a big chapter in the cancer tale}, keyword = {adaptive cellular response, cancer stemness, hypoxia, hypoxia-inducible factor 1, tumor progression} }
@article{article, author = {Ajdukovi\'{c}, Jasna}, year = {2016}, pages = {9-12}, keywords = {adaptive cellular response, cancer stemness, hypoxia, hypoxia-inducible factor 1, tumor progression}, journal = {Experimental oncology}, volume = {38}, number = {1}, issn = {0204-3564}, title = {HIF-1—a big chapter in the cancer tale}, keyword = {adaptive cellular response, cancer stemness, hypoxia, hypoxia-inducible factor 1, tumor progression} }

Časopis indeksira:


  • Scopus
  • MEDLINE





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