Synthesis, NMR and DFT study of ferrocenyl- triazole-nucleobase derivatives (CROSBI ID 664885)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Djaković, Senka ; Lapić, Jasmina ; Maračić, Silvija ; Vrček, Valerije ; Raić-Malić ; Silvana
engleski
Synthesis, NMR and DFT study of ferrocenyl- triazole-nucleobase derivatives
Ferrocenyl-nucleobase conjugates are of significant interest due to their potential application as electrochemically active biomarkers or anticancer active agents1. The incorporation of 1, 2, 3-triazoles as attractive linker units between two pharmacophores results in innovative bifunctional drugs. This has become increasingly useful and important approach in constructing bioactive molecules and functional molecules2. Herein we have described a preparation of compounds type I and II (Figure 1) via copper- catalyzed 1, 3-dipolar cycloaddition of azides and alkynes (CuAAC). The mono- and bis- ferrocenyl-uracil conjugates I and II were obtained by CuAAC reaction of 1- methylazidoferrocene or 1-azidoethylferrocene and N1- or N1/N3-propargyl uracil derivatives. The ferrocenyl units were introduced into different N-positions of N1/N3-propargyl uracil derivatives. Along with the major product (conjugate II), N1- or N3-monosubstituted derivatives may be formed. The regioselectivity of substitution in target products has been confirmed by spectroscopic analysis (1D and 2D- NMR, FTIR) and quantum chemical calculations (DFT level of theory).
ferrocenyl-triazole-nucleobase derivatives, synthesis, NMR and DFT study
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
442-442.
2018.
objavljeno
Podaci o matičnoj publikaciji
28th International Conference on Organometallic Chemistry
Peruzzini, M ; Mordini, A ; Gonsalvi, L
Firenza : München:
Podaci o skupu
28th International Conference on Bioorganometallic Chemistry (ICOMC2018)
poster
15.07.2018-20.07.2018
Firenca, Italija