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Pregled bibliografske jedinice broj: 9514

The multixenobiotic resistance mechanism in the marine sponge suberites domuncula - its potential applicability for the evaluation of environmental pollution by toxic compounds


Mueller, Werner E.G.; Stefen, Renate; Rinkevich, Baruch; Matranga, Valeria; Kurelec, Branko
The multixenobiotic resistance mechanism in the marine sponge suberites domuncula - its potential applicability for the evaluation of environmental pollution by toxic compounds // Marine biology, 125 (1996), 1; 165-170 doi:10.1007/BF00350770 (međunarodna recenzija, članak, znanstveni)


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Naslov
The multixenobiotic resistance mechanism in the marine sponge suberites domuncula - its potential applicability for the evaluation of environmental pollution by toxic compounds

Autori
Mueller, Werner E.G. ; Stefen, Renate ; Rinkevich, Baruch ; Matranga, Valeria ; Kurelec, Branko

Izvornik
Marine biology (0025-3162) 125 (1996), 1; 165-170

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
sponge cells ; multixenobiotic resistance ; binding ; accumulation ; pollution

Sažetak
Experiments were carried out with the marine sponge Suberites domuncala to determine whether sponges may express - like mammalian tumor cells a multidrug-like transporter system. The results demonstrate that sponge cells possess such a protective system termed multixenobiotic resistance (MXR) pump or P-glycoprotein-like pump, The protein was identified by antisera for the mammalian P170 multidrug resistance protein as a 130 kDa molecule, Binding studies were performed with H-3-vincristine (H-3-VCR) and membrane vesicles ; this process is ATP-dependent and inhibited by verapamil, which is known to reverse the multidrug-resistance phenotype in mammalian systems, Accumulation experiments were performed to demonstrate that the uptake of H-3-VCR is time-dependent, and increases at elevated extracellular levels of H-3-VCR, Application of the dyeing technique with calcein-AM, a suitable functional assay for multidrug transporter systems in mammal cells, also revealed the existence of the MXR pump in S. domuncula plasma membranes. These data demonstrate that S. domuncula is provided with a multidrug-like transporter, the MXR pump, which might function as a protection system for sponges in polluted environments

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
00981510

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Branko Kurelec (autor)

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Mueller, Werner E.G.; Stefen, Renate; Rinkevich, Baruch; Matranga, Valeria; Kurelec, Branko
The multixenobiotic resistance mechanism in the marine sponge suberites domuncula - its potential applicability for the evaluation of environmental pollution by toxic compounds // Marine biology, 125 (1996), 1; 165-170 doi:10.1007/BF00350770 (međunarodna recenzija, članak, znanstveni)
Mueller, W., Stefen, R., Rinkevich, B., Matranga, V. & Kurelec, B. (1996) The multixenobiotic resistance mechanism in the marine sponge suberites domuncula - its potential applicability for the evaluation of environmental pollution by toxic compounds. Marine biology, 125 (1), 165-170 doi:10.1007/BF00350770.
@article{article, year = {1996}, pages = {165-170}, DOI = {10.1007/BF00350770}, keywords = {sponge cells, multixenobiotic resistance, binding, accumulation, pollution}, journal = {Marine biology}, doi = {10.1007/BF00350770}, volume = {125}, number = {1}, issn = {0025-3162}, title = {The multixenobiotic resistance mechanism in the marine sponge suberites domuncula - its potential applicability for the evaluation of environmental pollution by toxic compounds}, keyword = {sponge cells, multixenobiotic resistance, binding, accumulation, pollution} }
@article{article, year = {1996}, pages = {165-170}, DOI = {10.1007/BF00350770}, keywords = {sponge cells, multixenobiotic resistance, binding, accumulation, pollution}, journal = {Marine biology}, doi = {10.1007/BF00350770}, volume = {125}, number = {1}, issn = {0025-3162}, title = {The multixenobiotic resistance mechanism in the marine sponge suberites domuncula - its potential applicability for the evaluation of environmental pollution by toxic compounds}, keyword = {sponge cells, multixenobiotic resistance, binding, accumulation, pollution} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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