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izvor podataka: crosbi

Correlation between immunological-inflammatory markers and endothelial disfunction in the early stage of coronary heart disease (CROSBI ID 254075)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Peršić, Viktor ; Bastiančić, Ana Lanca ; Rosović, Ivan ; Raljević, Damir ; Samsa, Dijana Travica ; Bastiančić, Luka ; Miškulin, Rajko ; Boban, Marko ; Laškarin, Gordana Correlation between immunological-inflammatory markers and endothelial disfunction in the early stage of coronary heart disease // Medical hypotheses, 115 (2018), 72-76. doi: 10.1016/j.mehy.2018.04.001

Podaci o odgovornosti

Peršić, Viktor ; Bastiančić, Ana Lanca ; Rosović, Ivan ; Raljević, Damir ; Samsa, Dijana Travica ; Bastiančić, Luka ; Miškulin, Rajko ; Boban, Marko ; Laškarin, Gordana

engleski

Correlation between immunological-inflammatory markers and endothelial disfunction in the early stage of coronary heart disease

Classical risk factors for endothelial dysfunction (ED), such as age, gender, total cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, and smoking history are utilised for the Framingham score and Systemic Coronary Risk Estimation (SCORE) for evaluation of the 10-year cardiovascular risk in routine practice. Nonetheless, pro-inflammatory mediators are deeply involved in the initiation and the progression of ED and coronary artery disease (CAD), and act additionally or independently of metabolic factors before clinical manifestations of the disease appear. C- reactive protein, a marker of intimal thickening of the myeloid- related protein 8/14 heterodimer, monocyte chemotactic protein 1, interleukin-15, the cytotoxic mediator, granulysin, and the matrix metalloproteinase 9 could be valuable, single, fast, and non- invasive laboratory tools for ED deterioration degree assessment. We propose to investigate the impact of pro-inflammatory biomarkers on ED, measured by previously established clinical methods in patients with yet undiagnosed CAD and at medium risk for an acute coronary event. It could be useful to measure and correlate the concentration of particular inflammatory markers in peripheral blood samples and the results of the Framingham and SCORE charts, multi-slice computed tomography coronary angiography, echocardiography, brachial artery flow-mediated dilatation, carotid-femoral pulse wave velocity, ankle-brachial index, carotid wall thickening, myocardial perfusion scintigraphy, and particularly, cardiac magnetic resonance imaging. The goal would be that the degree of correlation between particular inflammatory markers and the results of some methods for the assessment of ED or cardiac ischaemic imaging could be emphasised and pro-inflammatory markers positioned in the pathogenetic algorithm of CAD.

coronary angiography ; Agatston score ; coronary artery disease ; Framingham score ; granulysin ; interleukin-15

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Podaci o izdanju

115

2018.

72-76

objavljeno

0306-9877

1532-2777

10.1016/j.mehy.2018.04.001

Povezanost rada

Temeljne medicinske znanosti

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