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Pregled bibliografske jedinice broj: 951071

Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors


Rajić, Zrinka; Beus, Maja; Michnová, Hana; Vlainić, Josipa; Persoons, Leentje; Kosalec, Ivan; Jampílek, Josef; Schols, Dominique; Keser, Toma; Zorc, Branka
Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors // Molecules, 23 (2018), 7; 1724, 18 doi:10.3390/molecules23071724 (međunarodna recenzija, članak, znanstveni)


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Naslov
Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors

Autori
Rajić, Zrinka ; Beus, Maja ; Michnová, Hana ; Vlainić, Josipa ; Persoons, Leentje ; Kosalec, Ivan ; Jampílek, Josef ; Schols, Dominique ; Keser, Toma ; Zorc, Branka

Izvornik
Molecules (1420-3049) 23 (2018), 7; 1724, 18

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
fumardiamide ; primaquine ; succindiamide ; Michael acceptor ; biofilm eradication ; antibacterial screening ; antiviral activity ; cytostatic activity

Sažetak
Novel primaquine (PQ) and halogenaniline asymmetric fumardiamides 4a–f, potential Michael acceptors, and their reduced analogues succindiamides 5a–f were prepared by simple three-step reactions: coupling reaction between PQ and mono-ethyl fumarate (1a) or mono-methyl succinate (1b), hydrolysis of PQ-dicarboxylic acid mono-ester conjugates 2a, b to corresponding acids 3a, b, and a coupling reaction with halogenanilines. 1- [bis(Dimethylamino)methylene]-1H-1, 2, 3- triazolo[4, 5-b]pyridinium 3-oxide hexafluorophosphate (HATU) was used as a coupling reagent along with Hünig′s base. Compounds 4 and 5 were evaluated against a panel of bacteria, several Mycobacterium strains, fungi, a set of viruses, and nine different human tumor cell lines. p-Chlorofumardiamide 4d showed significant activity against Staphylococcus aureus, Streptococcus pneumoniae and Acinetobacter baumannii, but also against Candida albicans (minimum inhibitory concentration (MIC) 6.1–12.5 µg/mL). Together with p-fluoro and p-CF3 fumardiamides 4b, f, compound 4d showed activity against Mycobacterium marinum and 4b, f against M. tuberculosis. In biofilm eradication assay, most of the bacteria, particularly S. aureus, showed susceptibility to fumardiamides. m-CF3 and m- chloroaniline fumardiamides 4e and 4c showed significant antiviral activity against reovirus- 1, sindbis virus and Punta Toro virus (EC50 = 3.1–5.5 µM), while 4e was active against coxsackie virus B4 (EC50 = 3.1 µM). m-Fluoro derivative 4a exerted significant cytostatic activity (IC50 = 5.7–31.2 μM). Acute lymphoblastic leukemia cells were highly susceptible towards m-substituted derivatives 4a, c, e (IC50 = 6.7–8.9 μM). Biological evaluations revealed that fumardiamides 4 were more active than succindiamides 5 indicating importance of Michael conjugated system.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-1501 - Dizajniranje, sinteza i evaluacija derivata primakina, vorinostata i sorafeniba kao potencijalnih citostatika (HRZZ)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ivan Kosalec (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Josipa Vlainić (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Toma Keser (autor)

Avatar Url Maja Beus (autor)

Citiraj ovu publikaciju

Rajić, Zrinka; Beus, Maja; Michnová, Hana; Vlainić, Josipa; Persoons, Leentje; Kosalec, Ivan; Jampílek, Josef; Schols, Dominique; Keser, Toma; Zorc, Branka
Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors // Molecules, 23 (2018), 7; 1724, 18 doi:10.3390/molecules23071724 (međunarodna recenzija, članak, znanstveni)
Rajić, Z., Beus, M., Michnová, H., Vlainić, J., Persoons, L., Kosalec, I., Jampílek, J., Schols, D., Keser, T. & Zorc, B. (2018) Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors. Molecules, 23 (7), 1724, 18 doi:10.3390/molecules23071724.
@article{article, year = {2018}, pages = {18}, DOI = {10.3390/molecules23071724}, chapter = {1724}, keywords = {fumardiamide, primaquine, succindiamide, Michael acceptor, biofilm eradication, antibacterial screening, antiviral activity, cytostatic activity}, journal = {Molecules}, doi = {10.3390/molecules23071724}, volume = {23}, number = {7}, issn = {1420-3049}, title = {Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors}, keyword = {fumardiamide, primaquine, succindiamide, Michael acceptor, biofilm eradication, antibacterial screening, antiviral activity, cytostatic activity}, chapternumber = {1724} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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