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Pregled bibliografske jedinice broj: 950727

The urinary microbiome associated with bladder cancer


Bučević Popović, Viljemka; Šitum, Marijan; Chow, Cheryl-Emiliane T.; Chan, Luisa S.; Roje, Blanka; Terzić, Janoš
The urinary microbiome associated with bladder cancer // Scientific Reports, 8 (2018), 12157, 8 doi:10.1038/s41598-018-29054-w (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 950727 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The urinary microbiome associated with bladder cancer

Autori
Bučević Popović, Viljemka ; Šitum, Marijan ; Chow, Cheryl-Emiliane T. ; Chan, Luisa S. ; Roje, Blanka ; Terzić, Janoš

Izvornik
Scientific Reports (2045-2322) 8 (2018); 12157, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cancer, Fusobacterium, microbiome, urinary bladder

Sažetak
Recent findings suggest that human microbiome can influence the development of cancer, but the role of microorganisms in bladder cancer pathogenesis has not been explored yet. The aim of this study was to characterize and compare the urinary microbiome of bladder cancer patients with those of healthy controls. Bacterial communities present in urine specimens collected from 12 male patients diagnosed with bladder cancer, and from 11 healthy, age-matched individuals were analysed using 16S sequencing. Our results show that the most abundant phylum in both groups was Firmicutes , followed by Actinobacteria , Bacteroidetes and Proteobacteria . While microbial diversity and overall microbiome composition were not significantly different between groups, we could identify operational taxonomic units (OTUs) that were more abundant in either group. Among those that were significantly enriched in the bladder cancer group, we identified an OTU belonging to genus Fusobacterium , a possible protumorigenic pathogen. In an independent sample of 42 bladder cancer tissues, 11 had Fusobacterium nucleatum sequences detected by PCR. Three OTUs from genera Veillonella , Streptococcus and Corynebacterium were more abundant in healthy urines. However, due to the limited number of participants additional studies are needed to determine if urinary microbiome is associated with bladder cancer.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-1904 - Uloga upale u razvoju zloćudnog tumora mokraćnog mjehura (iBC) (Terzić, Janoš, HRZZ - 2014-09) ( POIROT)

Ustanove:
Prirodoslovno-matematički fakultet, Split,
Medicinski fakultet, Split

Citiraj ovu publikaciju

Bučević Popović, Viljemka; Šitum, Marijan; Chow, Cheryl-Emiliane T.; Chan, Luisa S.; Roje, Blanka; Terzić, Janoš
The urinary microbiome associated with bladder cancer // Scientific Reports, 8 (2018), 12157, 8 doi:10.1038/s41598-018-29054-w (međunarodna recenzija, članak, znanstveni)
Bučević Popović, V., Šitum, M., Chow, C., Chan, L., Roje, B. & Terzić, J. (2018) The urinary microbiome associated with bladder cancer. Scientific Reports, 8, 12157, 8 doi:10.1038/s41598-018-29054-w.
@article{article, year = {2018}, pages = {8}, DOI = {10.1038/s41598-018-29054-w}, chapter = {12157}, keywords = {cancer, Fusobacterium, microbiome, urinary bladder}, journal = {Scientific Reports}, doi = {10.1038/s41598-018-29054-w}, volume = {8}, issn = {2045-2322}, title = {The urinary microbiome associated with bladder cancer}, keyword = {cancer, Fusobacterium, microbiome, urinary bladder}, chapternumber = {12157} }
@article{article, year = {2018}, pages = {8}, DOI = {10.1038/s41598-018-29054-w}, chapter = {12157}, keywords = {cancer, Fusobacterium, microbiome, urinary bladder}, journal = {Scientific Reports}, doi = {10.1038/s41598-018-29054-w}, volume = {8}, issn = {2045-2322}, title = {The urinary microbiome associated with bladder cancer}, keyword = {cancer, Fusobacterium, microbiome, urinary bladder}, chapternumber = {12157} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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