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Pregled bibliografske jedinice broj: 950653

Calculating the effectiveness of some important anticancer herbal compounds against the main hallmarks of cancer


Tomić, Draško
Calculating the effectiveness of some important anticancer herbal compounds against the main hallmarks of cancer // 2018 41st International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO)
Opatija, Hrvatska, 2018. 22222, 4 doi:10.23919/MIPRO.2018.8400052 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


CROSBI ID: 950653 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Calculating the effectiveness of some important anticancer herbal compounds against the main hallmarks of cancer

Autori
Tomić, Draško

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
2018 41st International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO) / - , 2018

Skup
2018 41st International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO)

Mjesto i datum
Opatija, Hrvatska, 20-24 May 2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
anticancer herbal compounds, in silico models of cancer, hallmarks of cancer, oncogene proteins, interaction between molecules

Sažetak
There is a mounting evidence that certain herbal compounds express strong activity against various types of cancer cells. Curcumin from Curcuma longa, resveratrol from Vitis vinifera, and artemisinin from Artemisia annua are few examples from the longer list of more than fifty anticancer herbs known. This is mostly due to the extreme complexity of cancer processes that an exact mechanism of anticancer activity of these compounds is still unknown. However, with the rise of powerful supercomputers and the advanced in silico models of cancer, our chances to understand these processes increased, and now we are in place to deliver more effective therapies than ever before. KEGG (Kyoto Encyclopedia of Genes and Genomes) cancer pathways are example of such in silico models. From KEGG cancer pathways, we were able to identify sixty-two oncogene proteins involved in the development, proliferation, angiogenesis, metastasis and resistance of cancer. From them, we selected those having the largest number of hits in Pubmed database related to each of these cancer hallmarks, and use supercomputer for docking simulations between them and certain anticancer herbal compounds. Significant activity of anticancer herbal compounds against oncogene proteins was found. We hope our research will setup pathways towards more effective therapies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Interdisciplinarne biotehničke znanosti



POVEZANOST RADA


Ustanove:
Sveučilište u Rijeci - Odjel za informatiku

Profili:

Avatar Url Draško Tomić (autor)

Citiraj ovu publikaciju

Tomić, Draško
Calculating the effectiveness of some important anticancer herbal compounds against the main hallmarks of cancer // 2018 41st International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO)
Opatija, Hrvatska, 2018. 22222, 4 doi:10.23919/MIPRO.2018.8400052 (predavanje, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
Tomić, D. (2018) Calculating the effectiveness of some important anticancer herbal compounds against the main hallmarks of cancer. U: 2018 41st International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO) doi:10.23919/MIPRO.2018.8400052.
@article{article, author = {Tomi\'{c}, D.}, year = {2018}, pages = {4}, DOI = {10.23919/MIPRO.2018.8400052}, chapter = {22222}, keywords = {anticancer herbal compounds, in silico models of cancer, hallmarks of cancer, oncogene proteins, interaction between molecules}, doi = {10.23919/MIPRO.2018.8400052}, title = {Calculating the effectiveness of some important anticancer herbal compounds against the main hallmarks of cancer}, keyword = {anticancer herbal compounds, in silico models of cancer, hallmarks of cancer, oncogene proteins, interaction between molecules}, publisherplace = {Opatija, Hrvatska}, chapternumber = {22222} }
@article{article, author = {Tomi\'{c}, D.}, year = {2018}, pages = {4}, DOI = {10.23919/MIPRO.2018.8400052}, chapter = {22222}, keywords = {anticancer herbal compounds, in silico models of cancer, hallmarks of cancer, oncogene proteins, interaction between molecules}, doi = {10.23919/MIPRO.2018.8400052}, title = {Calculating the effectiveness of some important anticancer herbal compounds against the main hallmarks of cancer}, keyword = {anticancer herbal compounds, in silico models of cancer, hallmarks of cancer, oncogene proteins, interaction between molecules}, publisherplace = {Opatija, Hrvatska}, chapternumber = {22222} }

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