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Association between bone mineral density, bone remodeling markers and diet inflammatory index in women

Dietary intake has been shown to affect bone health via both proinflammatory and anti- inflammatory mechanisms. Some dietary constituents such as zinc, magnesium and calcium have anti-inflammatory effect and are beneficial for the bone physiology. The aim was to analyze bone mineral density (BMD), bone remodeling markers, serum vitamin D values and overall intake of the dietary minerals (calcium, magnesium, zinc and sodium) with respect to the dietary inflammatory index (DII) score. Women (N = 400) included in this study were divided in subgroups according to the adherence to DII score. Q1 indicated participants having the lowest DII values and highest adherence to anti-inflammatory diet, while Q4 were participants having pro- inflammatory diet. Kruskal–Wallis test was used to analyze the adherence of the bone status parameters to the DII score as well as the adherence of dietary minerals to DII score. Multiple regression analyses was employed to test the relationship between BMD and bone remodeling markers with the DII score and age. P\0.05 was considered as statistically significant. Our results revealed that women whose dietary habits were more in anti- inflammatory quartiles, had significantly higher values of the lumbar spine BMD (P = 0.01), left hip BMD (P\0.01) and bone alkaline phosphatase (P\0.01). They also had significantly higher intakes of dietary calcium, magnesium and zinc, P\0.01, respectively. Multiple regression analyses revealed that age and DII were significantly and inversely correlated to left hip BMD, while deoxypyridinoline was just proportional to age and DII, P\0.01, respectively. Study results suggest that anti-inflammatory diet is associated with high BMD and younger age.

bone mineral density, bone remodeling markers, dietary inflammatory index, women, age

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