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Pregled bibliografske jedinice broj: 949848

Development of method for determination of impurities in nepafenac by supercritical fluid chromatography


Runje, Mislav; Malev, Olga; Raič, Irena; Avdejev, Igor; Babić, Sandra
Development of method for determination of impurities in nepafenac by supercritical fluid chromatography // Book of abstracts "16th Ružička days TODAY SCIENCE – TOMORROW INDUSTRY" / Jukić, Ante ; Ocelić Bulatović, Vesna (ur.).
Osijek: Croatian Society of Chemical Engineers (CSCE), Faculty of Food Technology Osijek, University of Josip Juraj Strossmayer in Osijek, 2016. str. 34-34 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 949848 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Development of method for determination of impurities in nepafenac by supercritical fluid chromatography

Autori
Runje, Mislav ; Malev, Olga ; Raič, Irena ; Avdejev, Igor ; Babić, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts "16th Ružička days TODAY SCIENCE – TOMORROW INDUSTRY" / Jukić, Ante ; Ocelić Bulatović, Vesna - Osijek : Croatian Society of Chemical Engineers (CSCE), Faculty of Food Technology Osijek, University of Josip Juraj Strossmayer in Osijek, 2016, 34-34

ISBN
978-953-6894-58-1

Skup
16th Ružička days TODAY SCIENCE – TOMORROW INDUSTRY

Mjesto i datum
Vukovar, Hrvatska, 21.-23.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
supercritical fluid chromatography ; nepafenac

Sažetak
Nepafenac is chemically described as 2-amino-3- benzoylbenzeneacetamide manufactured as a 0.1% suspension for topical ophthalmic use and it belongs to a group of nonsteroidal anti- inflammatory drugs (NSAID). A novel simple, fast and efficient supercritical fluid chromatography (SFC) method was developed and compared with reversed-phase liquid chromatography (RPLC) method for the separation and determination of impurities in Nepafenac. Overall satisfactory resolutions and peak shapes for Nepafenac, 2- aminobenzophenone, Cl- thionepafenac, Thionepafenac, Cl-Nepafenac, Hydroxy Nepafenac and Cyclic Nepafenac were obtained by optimization of the chromatography system. With the gradient elution of mobile phase, all of the impurities and the active ingredient were separated within 6 min. Taking full advantage of features of SFC (such as particular selectivity, non-sloping baseline in gradient elution, and without solvent injection effects), the method was successfully used for determination of impurities in Nepafenac. More impurity peaks were detected, better resolution was achieved and much less analysis time was needed in comparison with conventional RPLC methods. The developed SFC method is validated with respect to specificity, LOD, LOQ, linearity, precision, accuracy and robustness.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
PLIVA HRVATSKA d.o.o.

Profili:

Avatar Url Olga Malev (autor)

Avatar Url Sandra Babić (autor)

Citiraj ovu publikaciju

Runje, Mislav; Malev, Olga; Raič, Irena; Avdejev, Igor; Babić, Sandra
Development of method for determination of impurities in nepafenac by supercritical fluid chromatography // Book of abstracts "16th Ružička days TODAY SCIENCE – TOMORROW INDUSTRY" / Jukić, Ante ; Ocelić Bulatović, Vesna (ur.).
Osijek: Croatian Society of Chemical Engineers (CSCE), Faculty of Food Technology Osijek, University of Josip Juraj Strossmayer in Osijek, 2016. str. 34-34 (poster, međunarodna recenzija, sažetak, znanstveni)
Runje, M., Malev, O., Raič, I., Avdejev, I. & Babić, S. (2016) Development of method for determination of impurities in nepafenac by supercritical fluid chromatography. U: Jukić, A. & Ocelić Bulatović, V. (ur.)Book of abstracts "16th Ružička days TODAY SCIENCE – TOMORROW INDUSTRY".
@article{article, year = {2016}, pages = {34-34}, keywords = {supercritical fluid chromatography, nepafenac}, isbn = {978-953-6894-58-1}, title = {Development of method for determination of impurities in nepafenac by supercritical fluid chromatography}, keyword = {supercritical fluid chromatography, nepafenac}, publisher = {Croatian Society of Chemical Engineers (CSCE), Faculty of Food Technology Osijek, University of Josip Juraj Strossmayer in Osijek}, publisherplace = {Vukovar, Hrvatska} }
@article{article, year = {2016}, pages = {34-34}, keywords = {supercritical fluid chromatography, nepafenac}, isbn = {978-953-6894-58-1}, title = {Development of method for determination of impurities in nepafenac by supercritical fluid chromatography}, keyword = {supercritical fluid chromatography, nepafenac}, publisher = {Croatian Society of Chemical Engineers (CSCE), Faculty of Food Technology Osijek, University of Josip Juraj Strossmayer in Osijek}, publisherplace = {Vukovar, Hrvatska} }




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