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The effect of subminimal inhibitory concentrations of antibiotics on the adherence ability of Pseudomonas aeruginosa to epithelial cells in vitro (CROSBI ID 253609)

Prilog u časopisu | kratko priopćenje | međunarodna recenzija

Bekić, Sanja ; Drenjančević, Domagoj ; Talapko, Jasminka ; Kotris, Ivan ; Škrlec, Ivana ; Vraneš, Jasmina The effect of subminimal inhibitory concentrations of antibiotics on the adherence ability of Pseudomonas aeruginosa to epithelial cells in vitro // Periodicum biologorum, 120 (2018), 2-3; 119-124. doi: 10.18054/pb.v120i2-3.6749

Podaci o odgovornosti

Bekić, Sanja ; Drenjančević, Domagoj ; Talapko, Jasminka ; Kotris, Ivan ; Škrlec, Ivana ; Vraneš, Jasmina

engleski

The effect of subminimal inhibitory concentrations of antibiotics on the adherence ability of Pseudomonas aeruginosa to epithelial cells in vitro

Background and purpose: The aim of this study was to examine the influence of subminimal inhibitory concentrations (subMICs) of ceftazidime, ciprofloxacin and gentamicin on the adherence ability and morphology of wild- type Pseudomonas aeruginosa strains to the Buffalo green monkey kidney cell line, using indirect immunofluorescence staining. Materials and methods: Bacterial adherence changes were tested before and after exposure to 1/2, 1/4, 1/8, 1/16 and 1/32 MIC of antibiotics. Results: A statistical difference in the number of attached bacteria after exposure to all subMICs of ceftazidime and ciprofloxacin was observed (p<0.05), even after only 1/2 MIC of gentamicin. Conclusion: The results of this study have shown that antibiotics in much lower concentrations than those necessary for inhibition of bacterial multiplications could damage the adherence of Pseudomonas aeruginosa to the epithelial cell line.

Ceftazidime ; Ciprofloxacin ; Gentamicin ; Bacterial adherence

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Podaci o izdanju

120 (2-3)

2018.

119-124

objavljeno

0031-5362

1849-0964

10.18054/pb.v120i2-3.6749

Povezanost rada

Kliničke medicinske znanosti, Temeljne medicinske znanosti

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