engleski

Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG

Comment to article entitled “A method to identify trace sulphated IgG N-glycans as biomarkers for rheumatoid arthritis”. The analytical method they used was very sensitive and powerful, providing results for glycans that represented only 0.005% of the glycome. They identified a total of 444 glycan structures and concluded that all these structures are N-glycans that are attached to immunoglobulin G (IgG). However, this glycomic analysis of IgG obtained by protein A purification does not account for the ubiquitous presence of varying levels of other contaminating plasma glycoproteins.

comment ; N-glycans ; plasma glycoproteins ; IgG

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