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Pregled bibliografske jedinice broj: 949229

Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer’s disease


Knezović, Ana; Osmanović Barilar, Jelena; Babić, Ana; Bagarić, Robert; Farkaš, Vladimir; Riederer, Peter; Šalković-Petrišić, Melita
Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer’s disease // Neuropharmacology, 135 (2018), 48-62 doi:10.1016/j.neuropharm.2018.02.027 (međunarodna recenzija, članak, znanstveni)


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Naslov
Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer’s disease

Autori
Knezović, Ana ; Osmanović Barilar, Jelena ; Babić, Ana ; Bagarić, Robert ; Farkaš, Vladimir ; Riederer, Peter ; Šalković-Petrišić, Melita

Izvornik
Neuropharmacology (0028-3908) 135 (2018); 48-62

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
oral galactose: streptozotocin ; intracerebroventricular, sporadic Alzheimer’s disease, memory ; glucagon-like peptide-1 ; 18fluorodeoxyglucose
(oral galactose ; streptozotocin ; intracerebroventricular, sporadic Alzheimer’s disease, memory ; glucagon-like peptide-1 ; 18fluorodeoxyglucose)

Sažetak
Insulin resistance and metabolic dysfunction in the brain are considered to be the pathophysiological core of sporadic Alzheimer's disease (sAD). In line with that fact, nutrients that could have therapeutic effects at this level have been investigated as possible targets in AD therapy. Galactose, an epimer of glucose, may serve as an alternative source of energy, and given orally may stimulate secretion of the incretin hormone glucagon-like peptide-1 (GLP-1). Our preliminary research indicated that oral galactose might prevent development of memory impairment in a rat model of sAD generated by intracerebroventricular administration of streptozotocin (STZ-icv). Here, we explored whether chronic oral galactose treatment could have beneficial effects on cognitive deficits already manifested at the time of initiation of galactose treatment in adult STZ-icv rats (treatment initiated 1 month after STZ-icv injection). The results clearly show that a 2- month exposure to oral galactose (200 mg/kg/day administered in a drink ad libitum) normalises impaired learning and memory functions. Memory improvement was accompanied by an improvement in brain glucose hypometabolism measured by 18fluorodeoxyglucosepositron emission tomography neuroimaging and by increments in active GLP-1 plasma levels as well as by an increased expression of GLP-1 receptors in the hippocampus and hypothalamus. Our findings provide strong evidence of beneficial effects of oral galactose treatment in the STZ-icv rat model of sAD and present possible underlying mechanisms including both direct effects of galactose within the brain and indirect GLP-1- induced neuroprotective effects that might open a new, dietary-based strategy in sAD treatment.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
HRZZ-IP-2014-09-4639 - TERAPIJSKI POTENCIJAL ORALNE GALAKTOZE U EKSPERIMENTALNOJ ALZHEIMEROVOJ BOLESTI (Petrišić Melita Šalković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Knezović, Ana; Osmanović Barilar, Jelena; Babić, Ana; Bagarić, Robert; Farkaš, Vladimir; Riederer, Peter; Šalković-Petrišić, Melita
Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer’s disease // Neuropharmacology, 135 (2018), 48-62 doi:10.1016/j.neuropharm.2018.02.027 (međunarodna recenzija, članak, znanstveni)
Knezović, A., Osmanović Barilar, J., Babić, A., Bagarić, R., Farkaš, V., Riederer, P. & Šalković-Petrišić, M. (2018) Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer’s disease. Neuropharmacology, 135, 48-62 doi:10.1016/j.neuropharm.2018.02.027.
@article{article, year = {2018}, pages = {48-62}, DOI = {10.1016/j.neuropharm.2018.02.027}, keywords = {oral galactose, streptozotocin, intracerebroventricular, sporadic Alzheimer’s disease, memory, glucagon-like peptide-1, 18fluorodeoxyglucose}, journal = {Neuropharmacology}, doi = {10.1016/j.neuropharm.2018.02.027}, volume = {135}, issn = {0028-3908}, title = {Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer’s disease}, keyword = {oral galactose, streptozotocin, intracerebroventricular, sporadic Alzheimer’s disease, memory, glucagon-like peptide-1, 18fluorodeoxyglucose} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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